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首页> 外文期刊>Journal of biochemical and molecular toxicology >Manganese accumulation in the mouse ear following systemic exposure.
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Manganese accumulation in the mouse ear following systemic exposure.

机译：全身性暴露后锰在小鼠耳中的积累。

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摘要

There is evidence in human populations that exposure to manganese (Mn), or Mn in combination with excessive noise exposure, results in hearing loss. Quantitative reverse-transcriptase polymerase chain reaction revealed expression of the metal transporters DMT1, ZIP8, and ZIP14 in control mouse ears. ZIP8 is known to have a high affinity (K(m) = 2.2 microM) for Mn transport, and ZIP8 protein was localized to the blood vessels of the ear by immunohistochemistry. We treated mice (strains C57BL/6J and DBA/2J) with Mn (100 mg/kg MnCl(2), by subcutaneous injection, on three alternating days), and Mn was significantly elevated in the ears of the treated mice. Mn concentrations remained elevated over controls for at least 2 weeks after treatment. These studies demonstrate that metal transporters are present in the mouse ear and that Mn can accumulate in the ear following systemic exposure. Future studies should focus on whether Mn exposure is associated with hearing deficits.
机译：在人群中有证据表明，接触锰（Mn）或Mn与过量的噪声接触会导致听力损失。定量逆转录酶聚合酶链反应揭示了金属转运蛋白DMT1，ZIP8和ZIP14在对照小鼠耳朵中的表达。已知ZIP8对Mn的转运具有高亲和力（K（m）= 2.2 microM），并且ZIP8蛋白通过免疫组织化学定位在耳朵的血管中。我们用锰（100 mg / kg MnCl（2），通过皮下注射，连续三天治疗小鼠（菌株C57BL / 6J和DBA / 2J），并且锰在治疗小鼠的耳朵中明显升高。治疗后至少2周，锰浓度仍高于对照组。这些研究表明，金属转运蛋白存在于小鼠的耳朵中，并且在全身暴露后，Mn可以在耳朵中积累。未来的研究应集中在锰暴露是否与听力障碍有关。

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