...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biochemical and molecular toxicology >Prophylactic and Therapeutic Potential of Acetyl-l-carnitine against Acetaminophen-Induced Hepatotoxicity in Mice
【24h】

Prophylactic and Therapeutic Potential of Acetyl-l-carnitine against Acetaminophen-Induced Hepatotoxicity in Mice

机译：乙酰-1-肉碱对乙酰氨基酚诱发的小鼠肝毒性的预防和治疗潜力

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Prophylactic and therapeutic effects of acetylcarnitine against acetaminophen-induced hepatotoxicity were studied in mice. To evaluate the prophylactic effects of acetylcarnitine, mice were supplemented with acetylcarnitine (2 mmol/kg/day per oral (p.o.) for 5 days) before a single dose of acetaminophen (350 mg/kg intraperitoneal (i.p.)). Animals were sacrificed 6 h after acetaminophen injection. Acetaminophen significantly increased the markers of liver injury, hepatic reactive oxygen species, and nitrateitrite, and decreased hepatic glutathione (GSH) and the antioxidant enzymes. Acetylcarnitine supplementation resulted in reversal of all biochemical parameters toward the control values. To explore the therapeutic effects of acetylcarnitine, mice were given a single dose of acetylcarnitine (0.5, 1, and 2 mmol/kg p.o.) 1.5 h after acetaminophen. Animals were sacrificed 6 h after acetaminophen. Acetylcarnitine administration resulted in partial reversal of liver injury only at 2 mmol/kg p.o. At equimolar doses, N-acetylcystiene was superior as therapeutic agent to acetylcarnitine. However, acetylcarnitine potentiated the effect of N-acetylcystiene in the treatment of acetaminophen toxicity.
机译：在小鼠中研究了乙酰肉碱对乙酰氨基酚引起的肝毒性的预防和治疗作用。为了评估乙酰肉碱的预防作用，在对乙酰氨基酚单剂量（350 mg / kg腹膜内（i.p.））之前，给小鼠补充乙酰肉碱（2 mmol / kg / day每口服（p.o.）持续5天）。对乙酰氨基酚注射后6小时处死动物。对乙酰氨基酚显着增加了肝损伤，肝活性氧和硝酸盐/亚硝酸盐的标志物，并降低了肝谷胱甘肽（GSH）和抗氧化酶。乙酰肉碱的补充导致所有生化参数向对照值的逆转。为了研究乙酰肉碱的治疗效果，对乙酰氨基酚1.5小时后，给小鼠单剂量乙酰肉碱（0.5、1和2 mmol / kg p.o.）。对乙酰氨基酚6 h后处死动物。乙酰肉碱给药仅以2 mmol / kg p.o导致肝损伤的部分逆转。在等摩尔剂量下，N-乙酰半胱氨酸作为治疗剂优于乙酰肉碱。但是，乙酰肉碱可增强N-乙酰半胱氨酸在对乙酰氨基酚毒性治疗中的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号