...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biochemical and molecular toxicology >Sex-specific effects of gestational and lactational coexposure to lead and cadmium on hepatic phase I and phase II xenobiotic/steroid-metabolizing enzymes and antioxidant status.
【24h】

Sex-specific effects of gestational and lactational coexposure to lead and cadmium on hepatic phase I and phase II xenobiotic/steroid-metabolizing enzymes and antioxidant status.

机译：妊娠和哺乳期共同暴露于铅和镉的性别特异性效应对肝I期和II期异生物素/类固醇代谢酶和抗氧化剂状态的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Liver has evolved complex enzymatic mechanisms to detoxify a wide array of xenobiotic substances, ranging from dietary components to environmental toxins to pharmaceuticals. Activities of many steroid-metabolizing enzymes in adult rat liver microsomes are sexually differentiated. Toxic effects of lead and cadmium on hepatic tissue have been well established in our earlier studies. We thus monitored the effects of gestational and lactational coexposure to lead and cadmium on hepatic phase I and phase II xenobiotic- and steroid-metabolizing enzyme activities in both male and female F1 generation postnatal day (PND) 56 rats. Adult pregnant female rats were treated subcutaneously [0.05 mg/(kg body wt. day)] with sodium acetate (control group), lead acetate, and cadmium acetate separately and in combination throughout the gestational and lactational period. Hepatic phase I xenobiotic-metabolizing enzymes (NADPH- and NADH-cytochrome c reductase) activities significantly decreased significantly in all the metal-treated groups in both PND 56 male and female rats as compared with the control group. Hepatic phase II enzymes (uridine diphosphate-glucuronosyl transferase, gamma-glutamyl transpeptidase, glutathione-S-transferase, 17-beta-hydroxysteroid oxidoreductase) were also highly susceptible to all the metal-treated groups. The observed alterations in the oxidative stress and biochemical parameters in the liver of F1 generation male and female rats resulted from an independent effect of lead and/or cadmium and also from their interaction. Results suggest that early developmental exposure to lead and cadmium both alone and in combination can suppress the hepatic xenobiotic-metabolizing enzyme activities in the liver of F1 generation male and female rats in a sex-dependent manner.
机译：肝脏已经进化出复杂的酶解机制，可以对从饮食成分到环境毒素再到药物的多种异种生物物质进行解毒。成年大鼠肝微粒体中许多类固醇代谢酶的活性是有性别差异的。铅和镉对肝组织的毒性作用已经在我们的早期研究中得到了很好的证实。因此，我们监测了妊娠和哺乳期共同暴露于铅和镉对雄性和雌性F1世代出生后（PND）56只大鼠的肝脏I期和II期异源生物和类固醇代谢酶活性的影响。成年怀孕的雌性大鼠在整个妊娠期和哺乳期分别用乙酸钠（对照组），乙酸铅和乙酸镉皮下注射[0.05 mg /（kg体重·天）]。与对照组相比，PND 56雄性和雌性大鼠的所有金属处理组中的肝I期异种生物代谢酶（NADPH和NADH-细胞色素c还原酶）活性均显着降低。肝II期酶（尿苷二磷酸-葡萄糖醛糖基转移酶，γ-谷氨酰转肽酶，谷胱甘肽-S-转移酶，17-β-羟基类固醇氧化还原酶）也对所有金属处理组高度敏感。 F1代雄性和雌性大鼠肝脏中观察到的氧化应激和生化参数的变化是由铅和/或镉的独立作用以及相互作用引起的。结果表明，单独和组合使用铅和镉的早期发育暴露可以以性别依赖性的方式抑制F1代雄性和雌性大鼠肝脏中肝异源代谢酶的活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号