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首页> 外文期刊>Journal of biochemical and molecular toxicology >Evaluation of comparative effect of pre- and posttreatment of selenium on mercury-induced oxidative stress, histological alterations, and metallothionein mRNA expression in rats.
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Evaluation of comparative effect of pre- and posttreatment of selenium on mercury-induced oxidative stress, histological alterations, and metallothionein mRNA expression in rats.

机译：评估硒的预处理前后对汞诱导的大鼠氧化应激，组织学改变和金属硫蛋白mRNA表达的比较作用。

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摘要

To evaluate the effect of pre- or posttreatment of selenium (6 micromol/kg b.w., single intraperitoneal injection) in mercury intoxication, rats were exposed to mercury (12 micromol/kg b.w., single intraperitoneal injection). Exposure to mercury resulted in induced oxidative stress in liver, kidney, and brain tissues. Marked changes in serum biochemical parameters together with alterations in histopathology and an induction in metallothionein-I and metallothionein-II mRNA expression in the liver and kidney were observed. Pretreatment with selenium to mercury-exposed animals had protective effect on the liver, whereas posttreatment had partial protection on restoration of altered oxidative stress parameters. In the kidney, pretreatment with selenium showed partial protection on restoration of altered biochemical parameters, whereas no protection was observed in posttreatment. The pretreatment with selenium resulted in restoration of mercury-induced metallothionein-I and metallothionein-II mRNA expression, which was completely restored in the liver whereas partial restoration was observed in the kidney. Posttreatment with selenium resulted in further induction in metallothionein-I and metallothionein-II mRNA expression in the liver and kidney. In the brain, selenium showed partial protection on alerted biochemical parameters. Results indicate that pretreatment with selenium is beneficial in comparison to posttreatment in mercury intoxication. Thus, dietary intake of selenium within safe limit may, therefore, enable us in combating any foreseen effects due to mercury exposure.
机译：为了评价硒的预处理或后处理（6 mol / kg b.w.，一次腹膜内注射）在汞中毒中的作用，将大鼠暴露于汞（12 mol / kg b.w.，一次腹膜内注射）。暴露于汞会在肝，肾和脑组织中引起氧化应激。观察到血清生化参数的显着变化以及组织病理学的改变，并诱导了肝脏和肾脏中金属硫蛋白-I和金属硫蛋白-II mRNA的表达。硒对汞暴露的动物进行预处理对肝脏具有保护作用，而对氧化应激参数的变化恢复则具有后处理作用。在肾脏中，硒预处理对恢复改变的生化参数显示出部分保护作用，而在后处理中未观察到保护作用。硒的预处理导致汞诱导的金属硫蛋白-I和金属硫蛋白-II mRNA表达的恢复，在肝脏中完全恢复，而在肾脏中观察到部分恢复。硒的后处理进一步诱导了肝脏和肾脏中金属硫蛋白-I和金属硫蛋白-II mRNA的表达。在大脑中，硒对机敏的生化指标显示出部分保护作用。结果表明，与汞中毒的后处理相比，硒的预处理是有益的。因此，饮食中硒的摄入量在安全限度内，可以使我们抵抗因汞暴露引起的任何预见的影响。

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