Optical microscopy is an important tool for studying live bio-1 ogical cells in life sciences research, enabling the observation of various biological processes in real time. The study of nanoscale single molecular activities such as protein-protein interactions is vital for understanding cellular processes and aids in the development of new drugs. Recent advances in imaging technology and labeling methodology have enabled the study of single biomol-ecules even within a cellular environment. It is -widely believed that optical microscopes have a finite resolution limit given by Rayleigh's criterion. This limitation has long been held as an impediment to studying nanoscale molecular interactions.
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