...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Circulation: An Official Journal of the American Heart Association >Effect of cardiac resynchronization therapy on reverse remodeling and relation to outcome: multicenter automatic defibrillator implantation trial: cardiac resynchronization therapy.
【24h】

Effect of cardiac resynchronization therapy on reverse remodeling and relation to outcome: multicenter automatic defibrillator implantation trial: cardiac resynchronization therapy.

机译：心脏再同步治疗对逆向重构的影响及其与预后的关系：多中心自动除颤器植入试验：心脏再同步治疗。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Cardiac resynchronization therapy (CRT) plus implantation of an implantable cardioverter defibrillator (ICD) reduced the risk of death or heart failure event in patients with mildly symptomatic heart failure, left ventricular dysfunction, and wide QRS complex compared with an ICD only. We assessed echocardiographic changes in patients enrolled in the MADIT-CRT trial (Multicenter Automatic Defibrillator Implantation Trial: Cardiac Resynchronization Therapy) to evaluate whether the improvement in outcomes with CRT plus an ICD was associated with favorable alterations in cardiac size and function. METHODS AND RESULTS: A total of 1,820 patients were randomly assigned to CRT plus an ICD or to an ICD only in a 3:2 ratio. Echocardiographic studies were obtained at baseline and 12 months later in 1,372 patients. We compared changes in cardiac size and performance between treatment groups and assessed the relationship between these changes over the first year, as well as subsequent outcomes. Compared with the ICD-only group, the CRT-plus-ICD group had greater improvement in left ventricular end-diastolic volume index (-26.2 versus -7.4 mL/m(2)), left ventricular end-systolic volume index (-28.7 versus -9.1 mL/m(2)), left ventricular ejection fraction (11% versus 3%), left atrial volume index (-11.9 versus -4.7 mL/m(2)), and right ventricular fractional area change (8% versus 5%; P<0.001 for all). Improvement in end-diastolic volume at 1 year was predictive of subsequent death or heart failure, with adjustment for baseline covariates and treatment group; each 10% decrease in end-diastolic volume was associated with a 40% reduction in risk (P<0.001). CONCLUSIONS: CRT resulted in significant improvement in cardiac size and performance compared with an ICD-only strategy in patients with mildly symptomatic heart failure. Improvement in these measures accounted for the outcomes benefit. Clinical Trial Registration Information- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00180271.
机译：背景：与仅使用ICD相比，心脏再同步治疗（CRT）加上植入式心脏复律除颤器（ICD）的植入降低了轻度症状性心力衰竭，左心功能不全和广泛QRS综合征患者的死亡或心力衰竭事件风险。我们评估了参加MADIT-CRT试验（多中心自动除颤器植入试验：心脏再同步治疗）的患者的超声心动图变化，以评估CRT加ICD改善预后是否与心脏大小和功能的良好改变相关。方法和结果：总共1,820名患者被随机分配为CRT加ICD或仅以3：2的比例分配给ICD。在基线和12个月后对1,372例患者进行了超声心动图研究。我们比较了治疗组之间心脏大小和性能的变化，并评估了第一年这些变化与后续结果之间的关系。与仅使用ICD的组相比，CRT加ICD组在左心室舒张末期容积指数（-26.2对-7.4 mL / m（2）），左心室舒张末期容积指数（-28.7）方面有更大的改善与-9.1 mL / m（2）相比），左心室射血分数（11％对3％），左心室容积指数（-11.9对-4.7 mL / m（2））和右心室分数面积变化（8％对比5％;所有P <0.001）。 1年时舒张末期容积的改善预示了随后的死亡或心力衰竭，并调整了基线协变量和治疗组。舒张末期容积每减少10％，风险降低40％（P <0.001）。结论：与仅使用ICD的策略相比，对于轻度症状性心力衰竭患者，CRT可以显着改善心脏的大小和性能。这些措施的改进说明了成果的益处。临床试验注册信息-URL：http：//www.clinicaltrials.gov。唯一标识符：NCT00180271。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号