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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Partitioning of four modern volatile general anesthetics into solvents that model buried amino acid side-chains.
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Partitioning of four modern volatile general anesthetics into solvents that model buried amino acid side-chains.

机译：将四种现代挥发性普通麻醉剂分配到模拟掩埋氨基酸侧链的溶剂中。

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摘要

Partitioning of four modern inhalational anesthetics (halothane, isoflurane, enflurane, and sevoflurane) between the gas phase and nine organic solvents that model different amino acid side-chains and lipid membrane domains was performed in an effort to define which microenvironments present in proteins and lipid bilayers might be favored. Compared to a purely aliphatic environment (hexane), the presence of an aromatic-, alcohol-, thiol- or sulfide group on the solvent improved anesthetic partitioning, by factors of 1.3-5.2 for halothane, 1.7-5.6 for isoflurane, 1.7-7.6 for enflurane, and 1.5-7.3 for sevoflurane. The most favorable solvent for halothane partitioning was ethyl methyl sulfide, a model for methionine. Enflurane and isoflurane partitioned most extensively into methanol, a model for serine, and sevoflurane into ethanol, a model for threonine. Isoflurane also partitioned favorably into ethyl methyl sulfide. The results suggest that volatile general anesthetics interact better with partly polar groups, which are present on amino acids frequently found buried in the hydrophobic core of proteins, compared to purely aliphatic side-chains. Furthermore, if an anesthetic molecule was located in a saturated region of a phospholipid bilayer membrane, there would be an energetically favorable driving force for it to move into several higher dielectric microenvironments present on membrane proteins. The results provide evidence that proteins rather than lipids are the likely targets of volatile general anesthetics in biological membranes.
机译：为了确定蛋白质和脂质中存在的微环境，对四种现代吸入麻醉剂（氟烷，异氟烷，庚烷和七氟醚）在气相与模拟不同氨基酸侧链和脂质膜结构域的九种有机溶剂之间进行了分配。双层可能会受到青睐。与纯脂族环境（己烷）相比，溶剂上芳族，醇，硫醇或硫化物基团的存在改善了麻醉剂的分配，氟烷为1.3-5.2，异氟烷为1.7-5.6，1.7-7.6恩氟烷的用量为1.5-7.3，七氟醚的用量为1.5-7.3。氟烷分配最有利的溶剂是甲硫氨酸的模型乙基甲基硫化物。恩氟烷和异氟烷最广泛地分配给甲醇（丝氨酸的模型），而七氟醚分配给乙醇（苏氨酸的模型）。异氟烷也有利地分配为乙基甲基硫化物。结果表明，与纯脂族侧链相比，挥发性全身麻醉药与部分极性基团相互作用更好，部分极性基团存在于蛋白质疏水核心中经常被发现的氨基酸上。此外，如果麻醉分子位于磷脂双层膜的饱和区域中，则将有能量上有利的驱动力，使其移动到膜蛋白上存在的几种较高介电的微环境中。结果提供了证据，证明蛋白质而不是脂质是生物膜中挥发性全身麻醉剂的可能靶标。

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