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首页> 外文期刊>Journal of Biotechnology >Lipophilic compounds in biotechnology - interactions with cells andtechnological problems
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Lipophilic compounds in biotechnology - interactions with cells andtechnological problems

机译：生物技术中的亲脂性化合物-与细胞的相互作用和技术问题

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摘要

Lipophilic compounds are of significant importance in modern biotechnology. Centerly of interest are the biodegradation as well as the biotransformation of such lipophilic and often water-immiscible substances. Both whole cells and/or enzymes are used for these processes. It is obvious that a wide range of problems arise in an application of such complex systems consisting of biocatalysts substrate(s), product(s), water, (in some cases water-immiscible organic solvents): (i) interactions between lipophilic compounds and the membranes resulting in the change of some physiological characteristics of the living system; (ii) problems in the transport of these compounds (substrates and/or products) within the complex structured reaction systems; (iii) the problem of increasing the solubility of the lipophilic and mostly water-immiscible compounds with a minimum of inhibition effects on the processes; (iv) the presence of lipophilic components may also cause changes of the transport processes within the system (e.g. immobilized cells) resulting in changed yield or activity of the biological system. These problems are critically discussed in this review in relation to the known modes of interaction of lipophilic compounds with membranes, the bioavailability of the substrates, and the cases of steroid biotransformations. An outlook of future aspects in research, development and application of such processes is given.
机译：亲脂性化合物在现代生物技术中非常重要。令人关注的焦点是这种亲脂性且常常与水不混溶的物质的生物降解以及生物转化。全细胞和/或酶都用于这些过程。显然，在由生物催化剂底物，产物，水（在某些情况下与水不混溶的有机溶剂）组成的这种复杂系统的应用中，会出现各种各样的问题：（i）亲脂性化合物之间的相互作用膜导致生物系统某些生理特性的改变; （ii）这些化合物（底物和/或产物）在复杂结构化反应系统中的运输问题; （iii）增加亲脂性化合物和大多数与水不混溶的化合物的溶解度而对工艺的抑制作用最小的问题; （iv）亲脂性组分的存在也可能引起系统（例如固定的细胞）内运输过程的改变，从而导致生物系统的产量或活性改变。这些问题是在有关亲脂性化合物与膜的相互作用的已知模式，底物的生物利用度以及类固醇生物转化的情况下进行的。展望了这些方法的研究，开发和应用的未来方面。

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