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CNS drug discovery: challenges and solutions.

机译：中枢神经系统药物发现：挑战和解决方案。

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The worldwide market for therapies for central nervous system (CNS) disorders was valued at around US dollars 50 billion in 2001, and is set to grow sharply in the years ahead. This is because of a marked increase in the number of people aged over 65 (the "baby boomer" effect), which will lead to increased demand for more safe and effective medicines for CNS disorders. This one-day Society for Medicines Research symposium, held September 23, 2004, in London, United Kingdom, was organized by Dr. Alan M. Palmer (Pharmidex, London, U.K.) and Prof. F. Anne Stephenson (School of Pharmacy, University of London, U.K.). More than 100 delegates heard a scholarly and comprehensive review of the challenges currently facing CNS research and development, which was accompanied by consideration of a variety of innovative solution strategies. The meeting considered: 1) how to identify and validate targets for potential CNS drugs; 2) how to assess brain penetration (both in vitro and in vivo); 3) how to develop in silico methodologies to predict blood-brain barrier penetration; 4) how to assess therapeutic efficacy (both in vitro and in vivo); 5) how to establish reliable biomarkers to guide decision making; and 6) how to effectively apply magnetic resonance imaging to CNS drug discovery.
机译：2001年，全球中枢神经系统（CNS）疾病治疗市场价值约为500亿美元，并且在未来几年中将急剧增长。这是因为65岁以上的人数显着增加（“婴儿潮”效应），这将导致对用于CNS疾病的更安全有效的药物的需求增加。这个为期一天的医学研究学会研讨会，于2004年9月23日在英国伦敦举行，由Alan M. Palmer博士（英国伦敦Pharmidex）和F. Anne Stephenson教授（英国药学院）共同组织。英国伦敦大学）。超过100位代表听取了关于CNS研究和开发当前面临的挑战的学术全面综述，同时还考虑了各种创新解决方案策略。会议审议了：1）如何确定和验证潜在的中枢神经系统药物的靶点; 2）如何评估大脑渗透率（体外和体内）; 3）如何开发计算机方法学来预测血脑屏障的渗透; 4）如何评估治疗效果（体外和体内）; 5）如何建立可靠的生物标志物来指导决策; 6）如何有效地将磁共振成像应用于中枢神经系统药物发现。

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