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首页> 外文期刊>Journal of biomaterials science >Solid free-form fabrication-based PCL/HA scaffolds fabricated with a multi-head deposition system for bone tissue engineering
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Solid free-form fabrication-based PCL/HA scaffolds fabricated with a multi-head deposition system for bone tissue engineering

机译：使用多头沉积系统制造的基于固体自由形式制造的PCL / HA支架，用于骨组织工程

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摘要

In this study, we fabricated polycaprolactone/hydroxyapatite (PCL/HA) scaffolds with a multi-head deposition system, a solid free-form fabrication technology that was developed in our previous study. The bone regeneration potential of the scaffolds was compared with that of PCL scaffolds fabricated with the same system. The fabricated scaffolds had a pore size of 400 μm and a porosity of 66.7%. The PCL/HA scaffolds had higher mechanical strength and modulus than the PCL scaffolds. To compare the osteogenic potential, the two types of scaffolds were seeded with rat osteoblasts and cultured in vitro or implanted subcutaneously into athymic mice. The cells cultured on PCL/HA scaffolds expressed higher levels of osteopontin and osteonectin, both of which are osteogenic proteins. The PCL/HA scaffolds resulted in larger bone area and calcium deposition in the implants compared to the PCL scaffolds.
机译：在这项研究中，我们使用多头沉积系统制造了聚己内酯/羟基磷灰石（PCL / HA）支架，该系统是我们先前研究中开发的固体自由形式制造技术。将支架的骨再生潜力与使用相同系统制造的PCL支架的骨再生潜力进行了比较。制成的支架的孔径为400μm，孔隙率为66.7％。 PCL / HA支架比PCL支架具有更高的机械强度和模量。为了比较成骨潜能，将两种类型的支架植入大鼠成骨细胞中，进行体外培养或将其皮下植入无胸腺小鼠中。在PCL / HA支架上培养的细胞表达更高水平的骨桥蛋白和骨连接蛋白，两者都是成骨蛋白。与PCL支架相比，PCL / HA支架在植入物中导致更大的骨面积和钙沉积。

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