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首页> 外文期刊>Journal of biomaterials science >Preparation and characterization of electrospun PLGA/gelatin nanofibers as a drug delivery system by emulsion electrospinning
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Preparation and characterization of electrospun PLGA/gelatin nanofibers as a drug delivery system by emulsion electrospinning

机译：乳液电纺制备电纺PLGA /明胶纳米纤维作为药物递送系统

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摘要

Novel biocompatible poly(lactide-co-glycolide) (PLGA) nanofiber mats with favorable biocompatibility and good mechanical strength were prepared, which could serve as an innovative type of tissue engineering scaffold or an ideal controllable drug delivery system. Both hydrophobic and hydrophilic drugs, Cefradine and 5-fluorouracil were successfully loaded into PLGA nanofiber mats by emulsion electrospinning. The natural bioactive protein gelatin (GE) was incorporated into the nanofiber mats to improve the surface properties of the materials for cell adhesion. Nanofibrous scaffolds were characterized by scanning electron microscopy, X-ray diffraction, differential scanning calorimetry, contact angle and tensile measurements. Emulsion electrospun fibers with GE had perfect hydrophilic and good mechanical property. The in vitro release test showed thedrugs released from emulsion electrospun fibers, which achieved lower burst release. The cells cytotoxicity experiment indicated that emulsion electrospun fibers were less toxic and tended to promote fibroblasts cells attachment and proliferation, which implied that the electrospun fibers had promising potential application in tissue engineering or drug delivery.
机译：制备了具有良好生物相容性和良好机械强度的新型生物相容性丙交酯-乙交酯共聚物（PLGA）纳米纤维垫，可作为一种创新型的组织工程支架或理想的可控药物递送系统。疏水性和亲水性药物Cefradine和5-氟尿嘧啶均通过乳液静电纺丝成功地装入PLGA纳米纤维垫中。将天然生物活性蛋白明胶（GE）掺入纳米纤维垫中，以改善用于细胞粘附的材料的表面性能。纳米纤维支架通过扫描电子显微镜，X射线衍射，差示扫描量热法，接触角和拉伸测量来表征。具有GE的乳液电纺纤维具有完美的亲水性和良好的机械性能。体外释放试验表明，药物从乳液电纺纤维中释放出来，从而实现了较低的破裂释放。细胞的细胞毒性实验表明，乳液电纺纤维的毒性较小，并倾向于促进成纤维细胞的附着和增殖，这表明电纺纤维在组织工程或药物输送中具有广阔的应用前景。

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