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首页> 外文期刊>Journal of Biomechanics >Computational biodynamics of human knee joint in gait: From muscle forces to cartilage stresses
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Computational biodynamics of human knee joint in gait: From muscle forces to cartilage stresses

机译：步态中人膝关节的计算生物力学：从肌肉力到软骨应力

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Using a validated finite element model of the intact knee joint we aim to compute muscle forces and joint response in the stance phase of gait. The model is driven by reported in vivo kinematics-kinetics data and ground reaction forces in asymptomatic subjects. Cartilage layers and menisci are simulated as depth-dependent tissues with collagen fibril networks. A simplified model with less refined mesh and isotropic depth-independent cartilage is also considered to investigate the effect of model accuracy on results. Muscle forces and joint detailed response are computed following an iterative procedure yielding results that satisfy kinematics/kinetics constraints while accounting at deformed configurations for muscle forces and passive properties. Predictions confirm that muscle forces and joint response alter substantially during the stance phase and that a simplified joint model may accurately be used to estimate muscle forces but not necessarily contact forces/areas, tissue stresses/strains, and ligament forces. Predictions are in general agreement with results of earlier studies. Performing the analyses at 6 periods from beginning to the end (0%, 5%, 25%, 50%, 75% and 100%), hamstrings forces peaked at 5%, quadriceps forces at 25% whereas gastrocnemius forces at 75%. ACL Force reached its maximum of 343. N at 25% and decreased thereafter. Contact forces reached maximum at 5%, 25% and 75% periods with the medial compartment carrying a major portion of load and experiencing larger relative movements and cartilage strains. Much smaller contact stresses were computed at the patellofemoral joint. This novel iterative kinematics-driven model is promising for the joint analysis in altered conditions.
机译：我们使用经过验证的完整膝关节有限元模型来计算步态站立阶段的肌肉力量和关节反应。该模型由无症状受试者体内的运动学动力学数据和地面反应力报告。软骨层和半月板被模拟为具有胶原纤维网络的深度依赖性组织。还考虑了具有较少精化网格和各向同性且与深度无关的软骨的简化模型，以研究模型准确性对结果的影响。遵循迭代过程计算出肌肉力和关节的详细响应，从而得到满足运动学/动力学约束的结果，同时考虑到变形后的构型的肌肉力和被动特性。预测证实，在站立阶段，肌肉力量和关节反应会发生实质性变化，简化的关节模型可以准确地用于估算肌肉力量，但不一定需要接触力/区域，组织应力/应变和韧带力。预测与早期研究的结果基本一致。从头到尾的6个周期（0％，5％，25％，50％，75％和100％）进行分析，the绳肌力达到5％峰值，股四头肌力达到25％，腓肠肌力达到75％。 ACL力量达到最大值343. N，为25％，此后有所下降。接触力在5％，25％和75％的时期达到最大值，内侧隔室承担着很大一部分负荷，并经历了较大的相对运动和软骨应变。在em股关节处计算出的接触应力小得多。这种新颖的迭代运动学驱动模型有望在变化的条件下进行联合分析。

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