...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Biomechanics >Experimental validation of a pulse wave propagation model for predicting hemodynamics after vascular access surgery
【24h】

Experimental validation of a pulse wave propagation model for predicting hemodynamics after vascular access surgery

机译：预测血管通路手术后血流动力学的脉搏波传播模型的实验验证

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hemodialysis patients require a vascular access that is, preferably, surgically created by connecting an artery and vein in the arm, i.e. an arteriovenous fistula (AVF). The site for AVF creation is chosen by the surgeon based on preoperative diagnostics, but AVFs are still compromised by flow-associated complications. Previously, it was shown that a computational 1D-model is able to describe pressure and flow after AVF surgery. However, predicted flows differed from measurements in 4/10 patients. Differences can be attributed to inaccuracies in Doppler measurements and input data, to neglecting physiological mechanisms or to an incomplete physical description of the pulse wave propagation after AVF surgery. The physical description can be checked by validating against an experimental setup consisting of silicone tubes mimicking the aorta and arm vasculature both before and after AVF surgery, which is the aim of the current study. In such an analysis, the output uncertainty resulting from measurement uncertainty in model input should be quantified. The computational model was fed by geometrical and mechanical properties collected from the setup. Pressure and flow waveforms were simulated and compared with experimental waveforms. The precision of the simulations was determined by performing a Monte Carlo study. It was concluded that the computational model was able to simulate mean pressures and flows accurately, whereas simulated waveforms were less attenuated than experimental ones, likely resulting from neglecting viscoelasticity. Furthermore, it was found that in the analysis output uncertainties, resulting from input uncertainties, cannot be neglected and should thus be considered.
机译：血液透析患者需要血管通路，该血管通路优选地是通过连接手臂中的动脉和静脉即动静脉瘘（AVF）而通过手术产生的。外科医生根据术前诊断选择要创建AVF的部位，但AVF仍会受到血流相关并发症的影响。先前已证明，计算的1D模型能够描述AVF手术后的压力和流量。但是，预测的流量与4/10位患者的测量值有所不同。差异可归因于多普勒测量和输入数据的不准确，生理机制的忽略或AVF手术后脉搏波传播的不完整物理描述。可以通过在包括AVF手术前后的模拟主动脉和手臂血管的硅胶管组成的实验装置中进行验证来检查其物理描述，这是当前研究的目的。在这种分析中，应量化由模型输入中的测量不确定性引起的输出不确定性。计算模型由从设置中收集的几何和机械特性提供。模拟压力和流量波形，并将其与实验波形进行比较。通过执行蒙特卡洛研究确定模拟的精度。结论是，该计算模型能够准确模拟平均压力和流量，而模拟波形的衰减比实验波形小，这可能是由于忽略了粘弹性造成的。此外，发现在分析中，由输入不确定性引起的输出不确定性不能忽略，因此应予以考虑。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号