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首页> 外文期刊>Journal of Biomechanics >Low-density lipoprotein transport within a multi-layered arterial wall-Effect of the atherosclerotic plaque/stenosis
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Low-density lipoprotein transport within a multi-layered arterial wall-Effect of the atherosclerotic plaque/stenosis

机译：低密度脂蛋白在多层动脉壁内的运输-动脉粥样硬化斑块/狭窄的影响

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摘要

Low-density lipoprotein (LDL) transport while incorporating the thickening of the arterial wall and cholesterol lipid accumulation is analyzed. A multi-layered model is adopted to represent the heterogeneity using the Darcy-Brinkman and Staverman filtration equations to describe transport within the porous layers of the wall. The fiber matrix model is utilized to represent the cholesterol lipid accumulation and the resulting variable properties. The impact of atherosclerotic wall thickening is shown to be negligible in the axial direction, but is found to be considerable in the radial direction within intima. The reference values of intima's porosity and effective fiber radius are obtained through the fiber matrix model, which characterizes the microstructure within the intima. Transport through dysfunctional endothelium and fibrous cap, and the impact on hydraulic and molecular transport properties by LDL accumulation in a thickened arterial wall is analyzed. The effect of variable properties on plasma and LDL molecular transport is also discussed.
机译：分析了低密度脂蛋白（LDL）的运输，同时合并了动脉壁的增厚和胆固醇脂质的积累。采用多层模型来表示异质性，使用Darcy-Brinkman和Staverman过滤方程式描述壁的多孔层内的传输。纤维基质模型用于表示胆固醇脂质的蓄积和所产生的可变特性。动脉粥样硬化壁增厚的影响在轴向上可忽略不计，但在内膜中在径向上却可观。内膜孔隙率和有效纤维半径的参考值是通过纤维基质模型获得的，该模型表征了内膜的微观结构。分析了通过功能障碍的内皮和纤维帽的转运，以及LDL在增厚的动脉壁中积累对水力和分子转运特性的影响。还讨论了可变性质对血浆和LDL分子转运的影响。

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