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首页> 外文期刊>Journal of Biomechanics >Biaxial and failure properties of passive rat middle cerebral arteries
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Biaxial and failure properties of passive rat middle cerebral arteries

机译：被动大鼠大脑中动脉的双轴和衰竭特性

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摘要

Rodents are commonly used as test subjects in research on traumatic brain injury and stroke. However, study of rat cerebral vessel properties has largely been limited to pressure-diameter response within the physiological loading range. A more complete, multiaxial description is needed to guide experiments on rats and rat vessels and to appropriately translate findings to humans. Accordingly, we dissected twelve rat middle cerebral arteries (MCAs) and subjected them to combined inflation and axial stretch tests around physiological loading conditions while in a passive state. The MCAs were finally stretched axially to failure. Results showed that MCAs under physiological conditions were stiffer in the axial than circumferential direction by a mean (±standard deviation) factor of 1.72 (±0.73), similar to previously reported behavior of human cerebral arteries. However, the stiffness for both directions was lower in rat MCA than in human cerebral arteries (p<0.01). Failure stretch values were higher in rat MCA (1.35±0.08) than in human vessels (1.24±0.09) (p=0.003), but corresponding 1st Piola Kirchhoff stress values for rats (0.42±0.09. MPa) were considerably lower than those for humans (3.29±0.64. MPa) (p<0.001). These differences between human and rat vessel properties should be considered in rat models of human cerebrovascular injury and disease.
机译：啮齿动物通常用作创伤性脑损伤和中风研究的测试对象。但是，对大鼠脑血管特性的研究在很大程度上仅限于生理负荷范围内的压力-直径响应。需要更完整的多轴描述来指导在大鼠和大鼠血管上进行的实验，并将发现的结果适当地转化为人类。因此，我们解剖了十二只大鼠大脑中动脉（MCA），并在处于被动状态时围绕生理负荷条件对其进行了充气和轴向拉伸测试。 MCA最终被轴向拉伸至失效。结果表明，在生理条件下，MCA在轴向上比圆周方向上的硬度要高，其平均（±标准偏差）因子为1.72（±0.73），与先前报道的人脑动脉行为相似。但是，大鼠MCA的两个方向的刚度均低于人脑动脉（p <0.01）。大鼠MCA的失效拉伸值（1.35±0.08）高于人血管（1.24±0.09）（p = 0.003），但是大鼠的相应第1 Piola Kirchhoff应力值（0.42±0.09。MPa）明显低于人人（3.29±0.64。MPa）（p <0.001）。在人脑血管损伤和疾病的大鼠模型中，应考虑人与大鼠血管特性之间的这些差异。

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