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首页> 外文期刊>Journal of Biomechanics >The influence of computational strategy on prediction of mechanical stress in carotid atherosclerotic plaques: Comparison of 2D structure-only, 3D structure-only, one-way and fully coupled fluid-structure interaction analyses
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The influence of computational strategy on prediction of mechanical stress in carotid atherosclerotic plaques: Comparison of 2D structure-only, 3D structure-only, one-way and fully coupled fluid-structure interaction analyses

机译：计算策略对颈动脉粥样硬化斑块机械应力预测的影响：仅2D结构，仅3D结构，单向和完全耦合的流固耦合分析的比较

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Background: Compositional and morphological features of carotid atherosclerotic plaques provide complementary information to luminal stenosis in predicting clinical presentations. However, they alone cannot predict cerebrovascular risk. Mechanical stress within the plaque induced by cyclical changes in blood pressure has potential to assess plaque vulnerability. Various modeling strategies have been employed to predict stress, including 2D and 3D structure-only, 3D one-way and fully coupled fluid-structure interaction (FSI) simulations. However, differences in stress predictions using different strategies have not been assessed. Methods: Maximum principal stress (Stress-P1) within 8 human carotid atherosclerotic plaques was calculated based on geometry reconstructed from in vivo computerized tomography and high resolution, multi-sequence magnetic resonance images. Stress-P1 within the diseased region predicted by 2D and 3D structure-only, and 3D one-way FSI simulations were compared to 3D fully coupled FSI analysis. Results: Compared to 3D fully coupled FSI, 2D structure-only simulation significantly overestimated stress level (94.1kPa [65.2, 117.3] vs. 85.5kPa [64.4, 113.6]; median [inter-quartile range], p=0.0004). However, when slices around the bifurcation region were excluded, stresses predicted by 2D structure-only simulations showed a good correlation (R2=0.69) with values obtained from 3D fully coupled FSI analysis. 3D structure-only model produced a small yet statistically significant stress overestimation compared to 3D fully coupled FSI (86.8kPa [66.3, 115.8] vs. 85.5kPa [64.4, 113.6]; p0.0001). In contrast, one-way FSI underestimated stress compared to 3D fully coupled FSI (78.8kPa [61.1, 100.4] vs. 85.5kPa [64.4, 113.7]; p0.0001). Conclusions: A 3D structure-only model seems to be a computationally inexpensive yet reasonably accurate approximation for stress within carotid atherosclerotic plaques with mild to moderate luminal stenosis as compared to fully coupled FSI analysis.
机译：背景：颈动脉粥样硬化斑块的组成和形态特征可为管腔狭窄提供补充信息，以预测临床表现。但是，仅靠他们自己并不能预测脑血管风险。由血压的周期性变化引起的斑块内的机械应力具有评估斑块易损性的潜力。已经采用了各种建模策略来预测应力，包括仅2D和3D结构，3D单向和完全耦合的流固耦合（FSI）模拟。但是，尚未评估使用不同策略进行的压力预测差异。方法：根据体内计算机断层扫描和高分辨率，多序列磁共振图像重建的几何形状，计算出8个人类颈动脉粥样硬化斑块中的最大主应力（Stress-P1）。通过仅2D和3D结构预测的患病区域内的应力P1以及3D单向FSI模拟与3D全耦合FSI分析进行了比较。结果：与3D全耦合FSI相比，仅2D结构的模拟显着高估了应力水平（94.1kPa [65.2，117.3]与85.5kPa [64.4，113.6];中位数[四分位数间距]，p = 0.0004）。但是，当排除分叉区域周围的切片时，仅2D结构模拟所预测的应力与从3D全耦合FSI分析获得的值显示出良好的相关性（R2 = 0.69）。与3D全耦合FSI相比，仅3D结构模型产生了较小的但统计学上显着的应力高估（86.8kPa [66.3，115.8]与85.5kPa [64.4，113.6]; p <0.0001）。相反，与3D全耦合FSI相比，单向FSI低估了应力（78.8kPa [61.1，100.4]与85.5kPa [64.4，113.7]; p <0.0001）。结论：与完全耦合的FSI分析相比，仅3D结构的模型似乎是轻度至中度管腔狭窄的颈动脉粥样硬化斑块内应力的计算廉价但合理准确的近似值。

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