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首页> 外文期刊>Journal of Biomechanics >The effects of tensile-compressive loading mode and microarchitecture on microdamage in human vertebral cancellous bone
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The effects of tensile-compressive loading mode and microarchitecture on microdamage in human vertebral cancellous bone

机译：拉伸压缩加载方式和微结构对人椎骨松质骨微损伤的影响

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The amount of microdamage in bone tissue impairs mechanical performance and may act as a stimulus for bone remodeling. Here we determine how loading mode (tension vs. compression) and microstructure (trabecular microarchitecture, local trabecular thickness, and presence of resorption cavities) influence the number and volume of microdamage sites generated in cancellous bone following a single overload. Twenty paired cylindrical specimens of human vertebral cancellous bone from 10 donors (47-78 years) were mechanically loaded to apparent yield in either compression or tension, and imaged in three dimensions for microarchitecture and microdamage (voxel size 0.7 x 0.7 x 5.0 mu m(3)). We found that the overall proportion of damaged tissue was greater (p = 0.01) for apparent tension loading (3.9 +/- 2.4%, mean +/- SD) than for apparent compression loading (1.9 +/- 1.3%). Individual microdamage sites generated in tension were larger in volume (p < 0.001) but not more numerous (p = 0.64) than sites in compression. For both loading modes, the proportion of damaged tissue varied more across donors than with bone volume fraction, traditional measures of microarchitecture (trabecular thickness, trabecular separation, etc.), apparent Young's modulus, or strength. Microdamage tended to occur in regions of greater trabecular thickness but not near observable resorption cavities. Taken together, these findings indicate that, regardless of loading mode, accumulation of microdamage in cancellous bone after monotonic loading to yield is influenced by donor characteristics other than traditional measures of microarchitecture, suggesting a possible role for tissue material properties. (C) 2014 Elsevier Ltd. All rights reserved.
机译：骨组织中的微损伤量会损害机械性能，并且可能会刺激骨骼重塑。在这里，我们确定加载方式（拉伸与压缩）和微结构（小梁微结构，局部小梁厚度以及存在吸收腔）如何影响单次过载后松质骨中产生的微损伤部位的数量和体积。将来自10个捐献者（47-78岁）的20对成对的椎体松质骨圆柱形标本以机械方式加载至压缩或拉伸状态下的表观屈服强度，并对三维结构和微损伤进行三维成像（体素尺寸0.7 x 0.7 x 5.0μm（ 3））。我们发现，表观拉伸负荷（3.9 +/- 2.4％，平均值+/- SD）比表观压缩负荷（1.9 +/- 1.3％）更大（p = 0.01）。拉伸产生的单个微损伤部位的体积比受压部位大（p <0.001），但数量不多（p = 0.64）。对于这两种加载模式，供体中受损组织的比例变化均大于骨骼体积分数，传统微结构测量（小梁厚度，小梁分离等），表观杨氏模量或强度。微损伤往往发生在小梁厚度较大的区域，但不会在可观察到的吸收腔附近发生。综上所述，这些发现表明，不管加载方式如何，单调加载至屈服后松质骨中微损伤的积累均受供体特征的影响，而不是传统的微体系结构，这暗示了组织材料特性的可能作用。 （C）2014 Elsevier Ltd.保留所有权利。

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