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首页> 外文期刊>Journal of Biomechanics >Is post-contrast MRI a valuable method for the study of the nutrition of the intervertebral disc?
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Is post-contrast MRI a valuable method for the study of the nutrition of the intervertebral disc?

机译：造影后MRI是否是研究椎间盘营养的有价值的方法？

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Decreased nutrition has been proposed as a potential mechanism leading to intervertebral disc degeneration. A method to investigate it in vivo is the MRI evaluation of the transport of a paramagnetic contrast agent, which is assumed to diffuse through the endplate to the disc using the same mechanisms as the cell nutrients. However, previous numerical studies questioned the value of this method as a model to investigate disc nutrition. To assess its validity, a parametric osmoporoelastic finite element model of a lumbar intervertebral disc incorporating diffusion and convection of a solute (representing the contrast agent) was developed. A Taguchi sensitivity analysis was performed in order to assess the relevance of various parameters which influence the solute transport. Subsequently, a full-factorial sensitivity analysis was used to investigate specifically the diffusion coefficients of the contrast agent. The most important parameters in determining the results were the disc height, the diffusion coefficients and the pharmacokinetic of the contrast agent. However, diffusion coefficients values as measured in in vitro studies would lead to insubstantial enhancement of the MRI signal. Thus, transport mechanisms other than pure diffusion should be active in in vivo transport of the contrast agent. In conclusion, the study showed that post-contrast MRI may not be suited for a quantitative analysis, but only for a qualitative examination aimed for example to detect endplate lesions. Open questions remain on the use of post-contrast MRI for the investigation of the relevance of reduced nutrition as a trigger to disc degeneration.
机译：营养下降被认为是导致椎间盘退变的潜在机制。在体内进行研究的一种方法是对顺磁性造影剂的运输进行MRI评估，假定使用与细胞营养物质相同的机制通过终板扩散到椎间盘。但是，以前的数值研究质疑这种方法作为研究椎间盘营养的模型的价值。为了评估其有效性，建立了结合了溶质（代表造影剂）的扩散和对流的腰椎间盘的参数渗透压弹性有限元模型。进行Taguchi灵敏度分析，以评估影响溶质迁移的各种参数的相关性。随后，使用全因子灵敏度分析来专门研究造影剂的扩散系数。决定结果的最重要参数是椎间盘高度，造影剂的扩散系数和药代动力学。但是，在体外研究中测得的扩散系数值将导致MRI信号的实质性增强。因此，在造影剂的体内转运中，除纯扩散以外的转运机制应是活跃的。总之，该研究表明，对比后MRI可能不适合进行定量分析，而仅适合于旨在检测终板病变的定性检查。关于使用造影剂后MRI来调查营养减少与椎间盘退变的相关性仍然存在悬而未决的问题。

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