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首页> 外文期刊>Journal of Biomechanics >Partial gravity unloading inhibits bone healing responses in a large animal model
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Partial gravity unloading inhibits bone healing responses in a large animal model

机译：在大型动物模型中，部分重力卸载抑制了骨愈合反应

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The reduction in mechanical loading associated with space travel results in dramatic decreases in the bone mineral density (BMD) and mechanical strength of skeletal tissue resulting in increased fracture risk during spaceflight missions. Previous rodent studies have highlighted distinct bone healing differences in animals in gravitational environments versus those during spaceflight. While these data have demonstrated that microgravity has deleterious effects on fracture healing, the direct translation of these results to human skeletal repair remains problematic due to substantial differences between rodent and human bone. Thus, the objective of this study was to investigate the effects of partial gravitational unloading on long-bone fracture healing in a previously-developed large animal Haversian bone model. In vivo measurements demonstrated significantly higher orthopedic plate strains (i.e. load burden) in the Partial Unloading (PU) Group as compared to the Full Loading (FL) Group following the 28-day healing period due to inhibited healing in the reduced loading environment. DEXA BMD in the metatarsus of the PU Group decreased 17.6% (p<0.01) at the time of the ostectomy surgery. Four-point bending stiffness of the PU Group was 4.4 times lower than that of the FL Group (p<0.01), while μCT and histomorphometry demonstrated reduced periosteal callus area (p<0.05), mineralizing surface (p<0.05), mineral apposition rate (p<0.001), bone formation rate (. p<0.001), and periosteal/endosteal osteoblast numbers (p<0.001/. p<0.01, respectively) as well as increased periosteal osteoclast number (p<0.05). These data provide strong evidence that the mechanical environment dramatically affects the fracture healing cascade, and likely has a negative impact on Haversian system healing during spaceflight.
机译：与太空旅行相关的机械负荷的减少导致骨骼矿物质密度（BMD）和骨骼组织机械强度的急剧下降，从而导致太空飞行任务中骨折风险的增加。先前的啮齿类动物研究强调了重力环境下动物与太空飞行过程中动物骨骼修复的显着差异。尽管这些数据已经证明微重力对骨折愈合具有有害作用，但是由于啮齿动物和人类骨骼之间的巨大差异，这些结果直接转化为人体骨骼修复仍然存在问题。因此，本研究的目的是在先前开发的大型动物哈弗斯骨模型中研究部分重力卸载对长骨骨折愈合的影响。体内测量结果显示，在28天的康复期后，由于在减少的负荷环境中抑制了愈合，因此与28负荷的满负荷（FL）组相比，部分负荷（PU）组的骨科钢板应变（即负荷负荷）明显更高。骨切除术时，PU组the骨的DEXA BMD降低了17.6％（p <0.01）。 PU组的四点弯曲刚度比FL组低4.4倍（p <0.01），而μCT和组织形态学检查显示骨膜call部面积减少（p <0.05），矿化表面（p <0.05），矿物沉积骨形成率（p <0.001），骨形成率（.p <0.001）和骨膜/骨膜成骨细胞数（p <0.001 /。p <0.01）以及骨膜破骨细胞数增加（p <0.05）。这些数据提供了有力的证据，表明机械环境极大地影响了骨折愈合的级联，并可能对航天飞行中的Haversian系统愈合产生负面影响。

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