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首页> 外文期刊>Journal of Biomechanics >In vivo simultaneous evaluations of sarcomere imaging and muscle fiber tension
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In vivo simultaneous evaluations of sarcomere imaging and muscle fiber tension

机译：肌瘤成像和肌纤维张力的体内同时评估

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摘要

Muscle fiber tension and sarcomere length play critical roles in regulating muscle functions and adaptations under pathological conditions. However, methods are lacking to quantify these two variables simultaneously in vivo. A novel force microscope was developed with the unique capabilities of estimating muscle fiber tension and acquiring sarcomere images simultaneously in vivo. The force microscope consisting of a custom microscopic imaging system and a force sensor was used to quantify in vivo sarcomere length, muscle fiber tension and stress of the tibialis cranialis muscle at plantar-flexed and dorsi-flexed positions from 11 rat hind limbs. Results showed that sarcomere images and fiber tension could be measured together in vivo with significantly higher muscle fiber tension and stress and longer sarcomere length at the plantar-flexed position when compared to their counterparts at the dorsi-flexed position. The fiber tension estimated using the force microscope had close agreement with the direct measurements of the fiber tension. The present force microscope with simultaneous characterizations of fiber tension and sarcomere imaging provides us a useful in vivo tool to investigate the roles of muscle tension in regulating sarcomere and muscle fiber functions under physiological and pathological conditions. (C) 2016 Elsevier Ltd. All rights reserved.
机译：在病理条件下，肌纤维张力和肌节长度在调节肌肉功能和适应性中起关键作用。然而，缺乏在体内同时量化这两个变量的方法。开发了一种新颖的力显微镜，其具有在体内同时估计肌肉纤维张力和获取肌节图像的独特功能。由定制的显微成像系统和力传感器组成的力显微镜用于量化11个大鼠后肢在plant屈和背屈位置的体内肌节长度，胫骨胫骨肌的肌纤维张力和应力。结果表明，与在背屈位相比，肌腱图像和纤维张力可以在体内同时测量，足底屈位的肌肉纤维张力和应力明显更高，而肌节长度更长。使用力显微镜估计的纤维张力与纤维张力的直接测量值非常一致。具有纤维张力和肌节成像的同时表征的本力显微镜为我们提供了一种有用的体内工具，用于研究在生理和病理条件下肌肉张力在调节肌节和肌纤维功能中的作用。 （C）2016 Elsevier Ltd.保留所有权利。

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