An integrated computational approach for aortic mechanics including geometric, histological and chemico-physical data

Bianchi Daniele; Marino Michele; Vairo Giuseppe

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An integrated computational approach for aortic mechanics including geometric, histological and chemico-physical data

机译：包含几何，组织学和化学物理数据的主动脉力学综合计算方法

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A novel computational approach for simulating aortic mechanical response is proposed. Patient-specific geometric description is coupled with a multiscale structurally-motivated tissue constitutive model, explicitly accounting for histological, biophysical and biochemical parameters. Accordingly, geometric and constitutive features can be straight included in highly-personalized numerical analyses, allowing to easily incorporate also effects related to possible pathological tissue defects. A parametric home-made code has been developed by integrating an image segmentation technique, a multiscale (nano-to-macro) tissue mechanical description, and a non-linear finite-element strategy. Preliminary numerical results, based on a case study involving a thoracic aortic segment, are presented and discussed, highlighting soundness and effectiveness of the adopted non-linear constitutive modeling. Moreover, the influence on the aortic macroscale response induced by a localized defect affecting the crimp of collagen fibers is analyzed, proving that the proposed multiscale computational framework is able to provide special insights into both etiology of some cardiovascular diseases and physio-pathological remodeling mechanisms. (C) 2016 Elsevier Ltd. All rights reserved.

机译：提出了一种模拟主动脉机械反应的新型计算方法。特定于患者的几何描述与多尺度结构驱动的组织本构模型相结合，明确考虑了组织学，生物物理和生化参数。因此，几何和本构特征可以直接包含在高度个性化的数值分析中，从而可以轻松地并入与可能的病理组织缺损相关的效应。通过集成图像分割技术，多尺度（纳米到宏观）组织机械描述和非线性有限元策略，已开发出参数化的自制代码。提出并讨论了基于涉及胸主动脉段的案例研究的初步数值结果，突出了所采用非线性本构模型的稳健性和有效性。此外，分析了局部缺陷对胶原纤维卷曲的影响对主动脉宏观反应的影响，证明了所提出的多尺度计算框架能够为某些心血管疾病的病因学和生理病理重塑机制提供特殊见解。（C）2016 Elsevier Ltd.保留所有权利。

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《Journal of Biomechanics》 |2016年第12期|共10页
作者
Bianchi Daniele; Marino Michele; Vairo Giuseppe;
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正文语种 eng
中图分类生物医学工程;
关键词
Aortic mechanics; Patient-specific computational models; Multiscale tissue modeling; Non-linear finite-element formulation; Cardiovascular diseases;

机译：主动脉力学;特定患者的计算模型;多尺度组织建模;非线性有限元公式化;心血管疾病;

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1. An integrated computational approach for aortic mechanics including geometric, histological and chemico-physical data [J] . Bianchi Daniele, Marino Michele, Vairo Giuseppe Journal of Biomechanics . 2016,第12期

机译：包含几何，组织学和化学物理数据的主动脉力学综合计算方法
2. Data Mining Over Biological Datasets: An Integrated Approach Based on Computational Intelligence [J] . Stegmayer G., Gerard M., Milone D.H. Computational Intelligence Magazine, IEEE . 2012,第4期

机译：生物数据集上的数据挖掘：基于计算智能的集成方法
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5. Histologic and geometric data challenge the assumption of habitual superior-inferior (tension-compression) bending across the chimpanzee proximal femur. [D] . Beckstrom, Adam Blake. 2010

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机译：几何计算力学与最优控制。

An integrated computational approach for aortic mechanics including geometric, histological and chemico-physical data

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