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首页> 外文期刊>Journal of Biomechanics >A personalized-model-based central aortic pressure estimation method
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A personalized-model-based central aortic pressure estimation method

机译：基于个性化模型的中心主动脉压力估计方法

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摘要

Central Aortic Pressure (CAP) can be used to predict cardiovascular structural damage and cardiovascular events, and the development of simple, well-validated and non-invasive methods for CAP waveforms estimation is critical to facilitate the routine clinical applications of CAP. Existing widely applied methods, such as generalized transfer function (GTF-CAP) method and N-Point Moving Average (NPMA-CAP) method, are based on clinical practices, and lack a mathematical foundation. Those methods also have inherent drawback that there is no personalisation, and missing individual aortic characteristics. To overcome this pitfall, we present a personalized-model-based central aortic pressure estimation method (PM-CAP)in this paper. This PM-CAP has a mathematical foundation: a human aortic network model is proposed which is developed based on viscous fluid mechanics theory and could be personalized conveniently. Via measuring the pulse wave at the proximal and distal ends of the radial artery, the least square method is then proposed to estimate patient-specific circuit parameters. Thus the central aortic pulse wave can be obtained via calculating the transfer function between the radial artery and central aorta. An invasive validation study with 18 subjects comparing PM-CAP with direct aortic root pressure measurements during percutaneous transluminal coronary intervention was carried out at the Beijing Hospital. The experimental results show better performance of the PM-CAP method compared to the GTF-CAP method and NPMA-CAP method, which illustrates the feasibility and effectiveness of the proposed method. (C) 2016 Elsevier Ltd. All rights reserved.
机译：中心动脉压（CAP）可用于预测心血管结构损伤和心血管事件，开发简单，有效且非侵入性的CAP波形估计方法对于促进CAP的常规临床应用至关重要。现有的广泛应用的方法，例如广义传递函数（GTF-CAP）方法和N点移动平均值（NPMA-CAP）方法，都是基于临床实践的，并且缺乏数学基础。这些方法还具有固有的缺点，即没有个性化，并且缺少个体主动脉特征。为了克服这个陷阱，本文提出了一种基于个性化模型的中心主动脉压力估计方法（PM-CAP）。该PM-CAP具有数学基础：提出了基于粘性流体力学理论开发的人的主动脉网络模型，该模型可以方便地进行个性化设置。通过测量radial动脉近端和远端的脉搏波，然后提出了最小二乘法来估计患者特定的电路参数。因此，可以通过计算the动脉和中央主动脉之间的传递函数来获得中央主动脉脉搏波。在北京医院进行了一项侵入性验证研究，研究对象是18位受试者，他们在经皮腔内冠状动脉介入治疗期间将PM-CAP与直接主动脉根压测量进行了比较。实验结果表明，与GTF-CAP方法和NPMA-CAP方法相比，PM-CAP方法具有更好的性能，说明了该方法的可行性和有效性。 （C）2016 Elsevier Ltd.保留所有权利。

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