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首页> 外文期刊>Journal of Biomechanics >Neutral solute transport across osteochondral interface: A finite element approach
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Neutral solute transport across osteochondral interface: A finite element approach

机译：跨骨软骨界面的中性溶质迁移：有限元方法

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Investigation of the solute transfer across articular cartilage and subchondrai bone plate could nurture the understanding of the mechanisms of osteoarthritis (OA) progression. In the current study, we approached the transport of neutral solutes in human (slight OA) and equine (healthy) samples using both computed tomography and biphasic-solute finite element modeling. We developed a multi-zone biphasic-solute finite element model (FEM) accounting for the inhomogeneity of articular cartilage (superficial, middle and deep zones) and subchondral bone plate. Fitting the FEM model to the concentration-time curves of the cartilage and the equilibrium concentration of the subchondral plate/calcified cartilage enabled determination of the diffusion coefficients in the superficial, middle and deep zones of cartilage and subchondral plate. We found slightly higher diffusion coefficients for all zones in the human samples as compared to the equine samples. Generally the diffusion coefficient in the superficial zone of human samples was about 3-fold higher than the middle zone, the diffusion coefficient of the middle zone was 1.5-fold higher than that of the deep zone, and the diffusion coefficient of the deep zone was 1.5-fold higher than that of the subchondral plate/calcified cartilage. Those ratios for equine samples were 9, 2 and 1.5, respectively. Regardless of the species considered, there is a gradual decrease of the diffusion coefficient as one approaches the subchondral plate, whereas the rate of decrease is dependent on the type of species. (C) 2016 Elsevier Ltd. All rights reserved.
机译：对跨关节软骨和软骨下骨板的溶质迁移的研究可以促进对骨关节炎（OA）进展机制的了解。在当前的研究中，我们使用计算机断层扫描和双相溶质有限元建模方法研究了人类（轻度OA）和马（健康）样品中中性溶质的运输。我们开发了一个多区域双相溶质有限元模型（FEM），以解决关节软骨（浅表，中部和深部区域）和软骨下骨板的不均匀性。将FEM模型拟合到软骨的浓度-时间曲线和软骨下板/钙化软骨的平衡浓度可以确定在软骨和软骨下板的浅，中，深区的扩散系数。我们发现，与马样品相比，人体样品中所有区域的扩散系数略高。通常，人类样品表层区域的扩散系数比中间区域高3倍左右，中间区域的扩散系数比深层区域高1.5倍，深层区域的扩散系数为3倍。比软骨下板/钙化软骨高1.5倍马样品的比率分别为9、2和1.5。无论考虑哪种物种，随着接近软骨下板，扩散系数都会逐渐降低，而降低的速率则取决于物种的类型。 （C）2016 Elsevier Ltd.保留所有权利。

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