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A physics based approach to the pulse wave velocity prediction in compliant arterial segments

机译：顺应性动脉节段中基于物理学的脉搏波速度预测方法

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Pulse wave velocity (PWV) quantification commonly serves. as a highly robust prognostic parameter being used in a preventative cardiovascular therapy. Being dependent on arterial elastance, it can serve as a marker of cardiovascular risk. Since it is influenced by a blood pressure (BP), the pertaining theory can lay the foundation in developing a technique for noninvasive blood pressure measurement. Previous studies have reported application of PWV, measured noninvasively, for both the estimation of arterial compliance and blood pressure, based on simplified physical or statistical models. A new theoretical model for pulse wave propagation in a compliant arterial segment is presented within the framework of pseudo-elastic deformation of biological tissue undergoing finite deformation. An essential ingredient is the dependence of results on nonlinear aspects of the model: convective fluid phenomena, hyperelastic constitutive relation, large deformation and a longitudinal pre-stress load. An exact analytical solution for PWV is presented as a function of pressure, flow and pseudo-elastic orthotropic parameters. Results from our model are compared with published in-vivo PWV measurements under diverse physiological conditions. Contributions of each of the nonlinearities are analyzed. It was found that the totally nonlinear model achieves the best match with the experimental data. To retrieve individual vascular information of a patient, the inverse problem of hemodynamics is presented, calculating local orthotropic hyperelastic properties of the arterial wall. The proposed technique can be used for "non-invasive assessment of arterial elastance, and blood pressure using direct measurement of PWV, with account of hyperelastic orthotropic properties. (C) 2016 Elsevier Ltd. All rights reserved.
机译：通常使用脉搏波速度（PWV）量化。作为用于预防性心血管治疗的高度可靠的预后参数。依赖于动脉弹性，它可以作为心血管风险的标志。由于它受血压（BP）的影响，因此相关理论可以为开发无创血压测量技术奠定基础。以前的研究已经报告了基于简化的物理或统计模型，无创测量的PWV在评估动脉顺应性和血压方面的应用。在顺应性动脉段中脉动波传播的新理论模型被提出在经历有限变形的生物组织的伪弹性变形的框架内。一个重要因素是结果依赖于模型的非线性方面：对流流体现象，超弹性本构关系，大变形和纵向预应力载荷。给出了PWV的精确解析解，它是压力，流量和拟弹性正交各向异性参数的函数。在不同的生理条件下，将我们模型的结果与已发表的体内PWV测量结果进行比较。分析了每个非线性的贡献。发现完全非线性模型与实验数据达到最佳匹配。为了检索患者的单个血管信息，提出了血流动力学的逆问题，计算了动脉壁的局部正交各向异性超弹性。考虑到超弹性的正交各向异性特性，建议的技术可用于“通过直接测量PWV来无创评估动脉弹性和血压。（C）2016 Elsevier Ltd.保留所有权利。

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