...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Biomechanics >The role of anisotropic expansion for pulmonary acinar aerosol deposition
【24h】

The role of anisotropic expansion for pulmonary acinar aerosol deposition

机译：各向异性膨胀在肺泡腺泡沉积中的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Lung deformations at the local pulmonary acinar scale are intrinsically anisotropic. Despite progress in imaging modalities, the true heterogeneous nature of acinar expansion during breathing remains controversial, where our understanding of inhaled aerosol deposition still widely emanates from studies under self-similar, isotropic wall motions. Building on recent 3D models of multi-generation acinar networks, we explore in numerical simulations how different hypothesized scenarios of anisotropic expansion influence deposition outcomes of inhaled aerosols in the acinar depths. While the broader range of particles acknowledged to reach the acinar region (d(p) = 0.005-5.0 mu m) are largely unaffected by the details of anisotropic expansion under tidal breathing, our results suggest nevertheless that anisotropy modulates the deposition sites and fractions for a narrow band of sub-micron particles (d(p) similar to 0.5-0.75 mu m), where the fate of aerosols is greatly intertwined with local convective flows. Our findings underscore how intrinsic aerosol motion (i.e. diffusion, sedimentation) undermines the role of anisotropic wall expansion that is often attributed in determining aerosol mixing and acinar deposition. (C) 2016 Elsevier Ltd. All rights reserved.
机译：局部肺腺泡尺度的肺变形本质上是各向异性的。尽管在成像方式方面取得了进展，但呼吸过程中腺泡扩张的真正异质性仍存在争议，在此，我们对吸入气溶胶沉积的理解仍广泛源自自相似，各向同性壁运动的研究。基于多代泡孔网络的最新3D模型，我们在数值模拟中探索了各向异性膨胀的不同假设情景如何影响泡孔深度中吸入气溶胶的沉积结果。尽管公认的到达腺泡区域的较宽范围的粒子（d（p）= 0.005-5.0μm）在很大程度上不受潮汐呼吸下各向异性膨胀的影响，但我们的结果表明，各向异性可调节沉积物的沉积部位和部分窄带的亚微米颗粒（d（p）类似于0.5-0.75微米），其中气溶胶的命运与局部对流密切相关。我们的发现强调了固有的气溶胶运动（即扩散，沉降）如何破坏各向异性壁膨胀的作用，而各向异性壁膨胀通常是确定气溶胶混合和腺泡沉积的原因。 （C）2016 Elsevier Ltd.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号