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首页> 外文期刊>Journal of Biomechanics >Contribution of elastin and collagen to the inflation response of the pig thoracic aorta: Assessing elastin's role in mechanical homeostasis
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Contribution of elastin and collagen to the inflation response of the pig thoracic aorta: Assessing elastin's role in mechanical homeostasis

机译：弹性蛋白和胶原蛋白对猪胸主动脉膨胀反应的贡献：评估弹性蛋白在机械稳态中的作用

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This study was undertaken to understand elastin's role in the mechanical homeostasis of the arterial wall. The mechanical properties of elastin vary along the aorta, and we hypothesized this maintained a uniform mechanical environment for the elastin, despite regional variation in loading. Elastin's physiological loading was determined by comparing the inflation response of intact and autoclave purified elastin aortas from the proximal and distal thoracic aorta. Elastin's stretch and stress depend on collagen recruitment. Collagen recruitment started in the proximal aorta at systolic pressures (13.3 to 14.6. kPa) and in the distal at sub-diastolic pressures (9.3 to 10.6. kPa). In the proximal aorta collagen did not contribute significantly to the stress or stiffness, indicating that elastin determined the vessel properties. In the distal aorta, the circumferential incremental modulus was 70% higher than in the proximal aorta, half of which (37%) was due to a stiffening of the elastin. Compared to the elastin tissue in the proximal aorta, the distal elastin suffered higher physiological circumferential stretch (29%, P=0.03), circumferential stress (39%, P=0.02), and circumferential stiffness (37%, P=0.006). Elastin's physiological axial stresses were also higher (67%, P=0.003). These findings do not support the hypothesis that the loading on elastin is constant along the aorta as we expected from homeostasis.
机译：进行这项研究是为了了解弹性蛋白在动脉壁机械稳态中的作用。弹性蛋白的机械特性沿主动脉变化，并且我们假设，尽管加载区域有所变化，但弹性蛋白的力学环境仍保持一致。弹性蛋白的生理负荷是通过比较来自胸主动脉近端和远端的完整和高压灭菌的纯化弹性蛋白主动脉的膨胀反应来确定的。弹性蛋白的拉伸和压力取决于胶原蛋白的募集。胶原蛋白的募集始于收缩压（13.3至14.6 kPa）的主动脉近端和舒张压较低（9.3至10.6 kPa）的远端主动脉。在主动脉近端，胶原蛋白对压力或僵硬度没有明显贡献，表明弹性蛋白决定了血管的性质。在远端主动脉中，周向模量比近端主动脉中高70％，其中一半（37％）归因于弹性蛋白的硬化。与近端主动脉中的弹性蛋白组织相比，远侧弹性蛋白具有较高的生理圆周拉伸度（29％，P = 0.03），圆周应力（39％，P = 0.02）和圆周刚度（37％，P = 0.006）。弹性蛋白的生理轴向应力也较高（67％，P = 0.003）。这些发现不支持这样的假设，即弹性蛋白的负荷沿着主动脉是恒定的，正如我们从稳态中所期望的那样。

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