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首页> 外文期刊>Journal of Biomechanics >Computer modeling of deployment and mechanical expansion of neurovascular flow diverter in patient-specific intracranial aneurysms
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Computer modeling of deployment and mechanical expansion of neurovascular flow diverter in patient-specific intracranial aneurysms

机译：特定患者颅内动脉瘤中神经血管分流器的展开和机械扩张的计算机建模

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Flow diverter (FD) is an emerging neurovascular device based on self-expandable braided stent for treating intracranial aneurysms. Variability in FD outcome has underscored a need for investigating the hemodynamic effect of fully deployed FD in patient-specific aneurysms. Image-based computational fluid dynamics, which can provide important hemodynamic insight, requires accurate representation of FD in deployed states. We developed a finite element analysis (FEA) based workflow for simulating mechanical deployment of FD in patient-specific aneurysms. We constructed FD models of interlaced wires emulating the Pipeline Embolization Device, using 3D finite beam elements to account for interactions between stent strands, and between the stent and other components. The FEA analysis encompasses all steps that affect the final deployed configuration including stent crimping, delivery and expansion. Besides the stent, modeling also includes key components of the FD delivery system such as microcatheter, pusher, and distal coil. Coordinated maneuver of these components allowed the workflow to mimic clinical operation of FD deployment and to explore clinical strategies. The workflow was applied to two patient-specific aneurysms. Parametric study indicated consistency of the deployment result against different friction conditions, but excessive intra-stent friction should be avoided. This study demonstrates for the first time mechanical modeling of braided FD stent deployment in cerebral vasculature to produce realistic deployed configuration, thus paving the way for accurate CFD analysis of flow diverters for reliable prediction and optimization of treatment outcome.
机译：分流器（FD）是一种基于自扩张式编织支架的新兴神经血管装置，用于治疗颅内动脉瘤。 FD结局的可变性已强调需要研究完全展开的FD在患者特异性动脉瘤中的血液动力学效应。基于图像的计算流体动力学（可提供重要的血液动力学见解）需要在部署状态下准确表示FD。我们开发了基于有限元分析（FEA）的工作流程，用于模拟FD在患者特定动脉瘤中的机械部署。我们使用3D有限梁单元解释了支架线之间以及支架与其他组件之间的相互作用，从而构建了模拟管道栓塞设备的交错线FD模型。 FEA分析包括影响最终部署配置的所有步骤，包括支架的压接，输送和扩展。除支架外，建模还包括FD输送系统的关键组件，例如微导管，推动器和远端线圈。这些组件的协调操作使工作流能够模仿FD部署的临床操作并探索临床策略。该工作流程应用于两个患者特定的动脉瘤。参数研究表明，在不同摩擦条件下，部署结果的一致性，但应避免支架内过度摩擦。这项研究首次证明了编织FD支架在脑脉管系统中的机械建模以产生逼真的展开构型，从而为分流器的精确CFD分析铺平了道路，从而可以可靠地预测和优化治疗结果。

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