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首页> 外文期刊>Journal of Biomechanics >Characterising skeletal muscle under large strain using eccentric and Fourier Transform-rheology
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Characterising skeletal muscle under large strain using eccentric and Fourier Transform-rheology

机译：使用偏心和傅立叶变换流变学表征大应变下的骨骼肌

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Characterising the passive anisotropic properties of soft tissues has been largely limited to the linear viscoelastic regime and shear loading is rarely done in the large deformation regime, despite the physiological significance of such properties. This paper demonstrates the use of eccentric rheology, which allows the anisotropy of skeletal muscle to be investigated. The large amplitude oscillatory strain properties of skeletal muscle were also investigated using Fourier Transform-theology. Histology was used to qualitatively assess the microstructure changes induced by large strain. Results showed that skeletal muscle was strongly anisotropic in the linear regime. The storage and loss moduli were found to be significantly different (p <0.05) between the three fibre alignment groups; for the group tested with fibres perpendicular to plane of shear was 123 +/- 1.3 kPa and 3.0 +/- 0.35 kPa, parallel to shear direction was 10.6 +/- 1.2 kPa and 2.4 +/- 0.23 kPa, and perpendicular to shear direction was 5.5 +/- 0.90 kPa and 1.3 +/- 0.21 kPa. The appearance and growth of higher order harmonics at large strain was different in the three testing directions indicating that the anisotropy of muscle affects skeletal muscle behaviour in the nonlinear regime. Histological analysis showed an increasing destruction of extracellular matrix and the rearrangement of fibres with increasing strain indicating mechanical damage at strains of larger than 10%. These microstructural changes could contribute to the complex nonlinear behaviour in skeletal muscle. This paper demonstrates a method of characterising the anisotropic properties in skeletal muscle under large strain whilst giving meaningful information on the physical response of tissue at various strains. (C) 2015 Elsevier Ltd. All rights reserved.
机译：表征软组织的被动各向异性的特性在很大程度上一直限于线性粘弹性状态，尽管在这种大变形状态下具有生理意义，但很少进行剪切加载。本文演示了偏心流变学的使用，它可以研究骨骼肌的各向异性。还使用傅立叶变换神学研究了骨骼肌的大振幅振荡应变特性。组织学用于定性评估大应变引起的微观结构变化。结果表明，骨骼肌在线性状态下具有强烈的各向异性。发现三个光纤排列组之间的储能模量和损耗模量有显着差异（p <0.05）;对于垂直于剪切平面的纤维进行测试的组，其垂直剪切方向为123 +/- 1.3 kPa和3.0 +/- 0.35 kPa，平行于剪切方向的纤维为10.6 +/- 1.2 kPa和2.4 +/- 0.23 kPa，并且垂直于剪切方向是5.5 +/- 0.90 kPa和1.3 +/- 0.21 kPa。在三个测试方向上，大应变下高次谐波的出现和增长是不同的，这表明在非线性条件下，肌肉的各向异性会影响骨骼肌的行为。组织学分析显示，随着应变的增加，细胞外基质的破坏增加，纤维重排，表明应变大于10％时发生机械损伤。这些微观结构的变化可能有助于骨骼肌复杂的非线性行为。本文演示了一种表征大应变下骨骼肌各向异性特性的方法，同时提供了有关各种应变下组织的物理反应的有意义的信息。 （C）2015 Elsevier Ltd.保留所有权利。

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