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首页> 外文期刊>Journal of Biomechanics >Computational modeling of the structure-function relationship in human placental terminal villi
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Computational modeling of the structure-function relationship in human placental terminal villi

机译：人胎盘末端绒毛结构-功能关系的计算模型

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Placental oxygen transport takes place at the final branches of the villous tree and is dictated by the relative arrangement of the maternal and fetal circulations. Modeling techniques have failed to accurately assess the structure-function relationship in the terminal villi due to the geometrical complexity. Three-dimensional blood flow and oxygen transport was modeled in four terminal villi reconstructed from confocal image stacks. The blood flow was analyzed along the center lines of capillary segments and the effect of the variability in capillary diameter, tortuosity and branching was investigated. Additionally, a validation study was performed to corroborate the simulation results. The results show how capillary variations impact motion of the fetal blood, and how their bends and dilatations can decelerate the flow by up to 80%. Vortical flow is also demonstrated not to develop in the fetal capillaries. The different geometries are shown to dictate the transport of gases with differences of over 100% in the oxygen flux between samples. Capillary variations are key for efficient oxygen uptake by the fetus; they allow the blood to decelerate where the villous membrane is thinnest allowing for a better oxygenation, but also by reducing the vessel diameter they carry the oxygenated blood away fast. The methodology employed herein could become a platform to simulate complicated in-vivo and in-vitro scenarios of pregnancy complications. (C) 2016 Elsevier Ltd. All rights reserved.
机译：胎盘氧气的运输发生在绒毛树的最后分支，由母体和胎儿循环的相对安排决定。由于几何复杂性，建模技术未能准确评估末端绒毛中的结构-功能关系。从共焦图像堆栈重建的四个末端绒毛中，对三维血流和氧气传输进行了建模。分析沿毛细血管段中心线的血流，并研究了毛细血管直径，曲折度和分支度变化的影响。此外，进行了一项验证研究以证实模拟结果。结果表明，毛细血管变化如何影响胎儿血液的运动，以及它们的弯曲和扩张如何使血流减速多达80％。胎儿毛细血管也没有显示出涡流。结果表明，不同的几何形状决定了气体的传输，样品之间的氧气通量相差超过100％。毛细管变化是胎儿有效吸收氧气的关键;它们使血液在绒毛膜最薄的地方减速，从而提供更好的氧合作用，而且还通过减小血管直径，使氧合的血液迅速带走。本文采用的方法可以成为模拟妊娠并发症复杂的体内和体外情况的平台。 （C）2016 Elsevier Ltd.保留所有权利。

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