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首页> 外文期刊>Journal of Biomechanics >Enhancing cell-free layer thickness by bypass channels in a wall
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Enhancing cell-free layer thickness by bypass channels in a wall

机译：通过壁中的旁路通道增加无细胞层的厚度

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摘要

When blood flows near a wall, red blood cells (RBCs) drift away from the wall and a cell-free layer (CFL) is formed adjacent to the wall. Controlling the CFL thickness is important for preventing adhesion of cells in the design of biomedical devices. In this study, a novel wall configuration with stenoses and bypass channels is proposed to increase the CFL thickness. We found that the presence of bypass channels modified the spatial distribution of cells and substantially increased the CFL downstream of the stenosis. A single-bypass geometry with 5% hematocrit (Hct) blood flow showed a 1.7 mu m increase in CFL thickness compared to without the bypass. In the case of three bypass channels, a 3 gm increase in CFL thickness was observed. The CFL enhancement was observed up to 10% Hct, but no significant enhancement of CFL was indicated for 20% Hct blood flow. The mechanism of the CFL enhancement was investigated using a numerical simulation of the flow field. The results showed that the distance between each streamline and the corner of the stenosis compared with size of RBC was important parameter in regulating CFL thickness. These results show the potential of the proposed mechanism to prevent adhesion of cells to biomedical devices. (C) 2015 Elsevier Ltd. All rights reserved.
机译：当血液在壁附近流动时，红细胞（RBC）会从壁上漂移，并在壁附近形成无细胞层（CFL）。在生物医学设备的设计中，控制CFL厚度对于防止细胞粘附很重要。在这项研究中，提出了一种具有狭窄和旁路通道的新型壁结构，以增加CFL的厚度。我们发现旁路通道的存在改变了细胞的空间分布，并显着增加了狭窄下游的CFL。与不使用旁路的血流相比，血流比容（Hct）为5％的单旁路几何形状的CFL厚度增加了1.7微米。在三个旁路通道的情况下，观察到CFL厚度增加了3 gm。观察到高达10％Hct的CFL增强，但是对于20％Hct的血流，没有显示CFL​​的显着增强。使用流场的数值模拟研究了CFL增强的机理。结果表明，与RBC大小相比，各条流线与狭窄角之间的距离是调节CFL厚度的重要参数。这些结果表明了所提出的机制防止细胞粘附于生物医学装置的潜力。 （C）2015 Elsevier Ltd.保留所有权利。

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