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首页> 外文期刊>Journal of Biomechanics >Design and validation of a bioreactor for engineering vocal fold tissues under combined tensile and vibrational stresses
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Design and validation of a bioreactor for engineering vocal fold tissues under combined tensile and vibrational stresses

机译：拉伸和振动共同作用下工程声带组织的生物反应器的设计和验证

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Criteria are outlined for the design of a bioreactor that can simulate the vibrational stresses in vocal fold movement during speech. Requirements are 0-1 mm amplitudes in the 20-200 Hz frequency range, a variable on-off stress regime, and maintenance of tissue viability over several days. The bioreactor uses dual drivers, one for low frequency (or static) strains, and another for high-frequencies vibrational strains. Response is linear at the driving end for an input of 0-5 V. The amplitude decreases linearly with frequency at constant input voltage, and the phase changes by nearly 180degrees over the 20-200 Hz range. Human vocal fold fibroblasts were cultured in a polymer substrate and subjected to static and vibrational forces. The results indicate that vibratory strain alters the expression levels of many extracellular matrix-related genes, as well as the spatial distribution of cells and matrix. (C) 2004 Elsevier Ltd. All rights reserved.
机译：概述了设计生物反应器的标准，该反应器可以模拟语音中声带运动中的振动应力。要求是在20-200 Hz频率范围内的0-1 mm振幅，可变的开关应力范围以及在几天内维持组织活力。生物反应器使用双驱动器，一个驱动器用于低频（或静态）应变，另一个驱动器用于高频振动应变。输入电压为0-5 V时，驱动端的响应是线性的。在恒定输入电压下，幅度随频率线性降低，并且在20-200 Hz的范围内，相位变化了近180度。将人声折叠成纤维细胞在聚合物基质中培养，并使其受到静力和振动力的作用。结果表明，振动应变改变了许多细胞外基质相关基因的表达水平，以及细胞和基质的空间分布。 （C）2004 Elsevier Ltd.保留所有权利。

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