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首页> 外文期刊>Journal of Biomechanics >On the influence of mechanical conditions in osteochondral defect healing
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On the influence of mechanical conditions in osteochondral defect healing

机译：机械条件对骨软骨缺损愈合的影响

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Despite the introduction of new surgical techniques, the treatment of cartilage defects remains challenging. Delay or complete failure of cartilage healing is associated with problems in biological regeneration. The influence of mechanical conditions on this process, however, remains unevaluated.Osteochondral defects were generated on the left femoral condyle in 18 Yucatan minipigs. After 4, 6 and 12 weeks the defect filling, trabecular orientation and bone density were compared to the intact contralateral side. The mechanical straining during this period was then analyzed using an adaptive finite element technique.Histologically, the osteochondral defects showed bone resorption at the base and bone formation from the circumference. At 12 weeks, the macroscopically healed specimens showed fibrous cartilage formation, a minimally organized trabecular structure and increased trabecular volume fraction compared to the controls (p < 0.002). The amount of cancellous, cartilagineous, and fibrous tissue and the defect size as measured in histomorphometric analysis for the three time points (4, 6 and 12 weeks) was comparable in magnitude to that predicted by finite element analysis. The simulated osteochondral healing process was not fully capable of reestablishing a hyaline-like cartilage layer. The correlation between simulation and histology allows identification of mechanical factors that appear to have a larger impact on the healing of osteochondral defects than previously considered. (c) 2004 Elsevier Ltd. All rights reserved.
机译：尽管引入了新的外科手术技术，但是软骨缺陷的治疗仍然具有挑战性。软骨愈合的延迟或完全失败与生物再生中的问题有关。然而，机械条件对这一过程的影响仍未得到评估。在18尤卡坦小型猪的左股骨dy中产生骨软骨缺损。在第4、6和12周后，将缺损的填充，小梁的方向和骨密度与完整的对侧进行比较。然后使用自适应有限元技术分析此期间的机械应变。组织学上，骨软骨缺损显示了基部的骨吸收和周围的骨形成。与对照组相比，在第12周时，经肉眼观察到愈合的标本显示出纤维软骨形成，最小组织的小梁结构和小梁体积分数增加（p <0.002）。在三个时间点（4、6和12周）的组织形态计量学分析中测得的松质，软骨和纤维组织的数量以及缺损的大小与有限元分析的预测值相当。模拟的骨软骨愈合过程不能完全重建透明样软骨层。模拟和组织学之间的相关性允许识别似乎比以前考虑的对骨软骨缺损愈合影响更大的机械因素。 （c）2004 Elsevier Ltd.保留所有权利。

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