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首页> 外文期刊>Journal of Biomechanics >THE TENSILE BEHAVIOR OF DEMINERALIZED BOVINE CORTICAL BONE
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THE TENSILE BEHAVIOR OF DEMINERALIZED BOVINE CORTICAL BONE

机译：半矿化牛骨皮质骨的拉伸行为

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Bone is frequently modeled as a two-phase composite of hydroxyapatite mineral crystals dispersed throughout an organic collagen matrix. However, because of the numerous limitations (e.g. small sample size, poor strain measuring techniques, rapid demineralization with acids) of previous mechanical tests of bone with its hydroxyapatite chemically removed, we have determined new, accurate data on the material properties of the demineralized bone matrix for use in these composite models. We performed tensile tests on waisted specimens of demineralized bovine cortical bone from six humeral diaphyses. Specimens were demineralized over 14 days with a 0.5 M disodium EDTA solution that was replaced daily. Atomic absorption spectrophotometry was used to track the demineralization process and to determine the effectiveness of our demineralization protocol. Mechanical tests were performed at room temperature under displacement control at an approximate strain rate of 0.5% per s. We imposed nine preconditioning cycles before a final ramp to failure, and measured gauge length displacements using a non-invasive optical technique. The resulting stress-strain curves were similar to the tensile behavior observed in mechanical tests of other collagenous tissues, exhibiting an initial non-linear 'toe' region, followed by a linear region and subsequent failure without evidence of yielding. We found an average modulus, ultimate stress, and ultimate strain of 613 MPa (S.D. = 113 MPa), 61.5 MPa (S.D. = 13.1 MPa), and 12.3% (S.D. = 0.5%), respectively. Our average modulus is approximately half the value frequently used in current composite bone analyses. These data should also have clinical relevance because the early strength of healing fractured bone depends largely on the material properties of the collagen matrix. Copyright (C) 1996 Elsevier Science Ltd. [References: 42]
机译：骨骼通常被建模为分散在整个有机胶原基质中的羟磷灰石矿物晶体的两相复合物。但是，由于以前的化学方法（化学方法去除了羟基磷灰石）对骨骼进行了机械测试，因此存在诸多局限性（例如，样本量小，应变测量技术差，酸快速脱矿），因此我们确定了脱矿骨材料特性的新的准确数据这些复合模型中使用的矩阵。我们对来自六个肱骨干骨的脱矿质牛皮质骨的腰部标本进行了拉伸测试。用0.5 M EDTA二钠溶液每天14天对样品进行软化处理。原子吸收分光光度法用于跟踪脱盐过程并确定我们的脱盐方案的有效性。在室温下在位移控制下以约0.5％/ s的应变速率进行机械测试。我们在最终的故障斜坡之前施加了9个预处理周期，并使用无创光学技术测量了标距长度位移。所得的应力-应变曲线类似于在其他胶原组织的机械测试中观察到的拉伸行为，表现出最初的非线性“趾”区域，随后是线性区域，随后失效而没有屈服的迹象。我们发现平均模量，极限应力和极限应变分别为613 MPa（S.D. = 113 MPa），61.5 MPa（S.D. = 13.1 MPa）和12.3％（S.D. = 0.5％）。我们的平均模量大约是当前复合骨分析中经常使用的值的一半。这些数据也应具有临床意义，因为愈合骨折的骨的早期强度在很大程度上取决于胶原蛋白基质的材料特性。版权所有（C）1996 Elsevier Science Ltd. [引用：42]

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