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首页> 外文期刊>Journal of Biomechanics >High resolution mechanical function in the intact porcine heart: mechanical effects of pacemaker location.
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High resolution mechanical function in the intact porcine heart: mechanical effects of pacemaker location.

机译：完整猪心脏中的高分辨率机械功能：起搏器位置的机械作用。

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The necessity to quantify the mechanical function with high spatial resolution stemmed from the advancement of myocardial salvaging techniques. Since these therapies are localized interventions, a whole field technique with high spatial resolution was needed to differentiate the normal, diseased, and treated myocardium. We developed a phase correlation algorithm for measuring myocardial displacement at high spatial resolution and to determine the regional mechanical function in the intact heart. Porcine hearts were exposed and high contrast microparticles were placed on the myocardium. A pressure transducer, inserted into the left ventricle, synchronized the pressure (LVP) with image acquisition using a charge-coupled device camera. The deformation of the myocardium was measured with a resolution of 0.58+/-0.04 mm. Within the region of interest (ROI), regional stroke work (RSW), defined as the integral of LVP with respect to regional area, was determined on average at 21 locations with a resolution of 27.1+/-2.7 mm2. To alter regional mechanical function, the heart was paced at three different locations around the ROI. Independent of the pacemaker location, RSW decreased in the ROI. In addition, a gradient of increasing RSW in the outward direction radiating from the pacemaker was observed in all pacing protocols. These data demonstrated the ability to determine regional whole field mechanical function with high spatial resolution, and the significant alterations induced by electrical pacing.
机译：由于心肌抢救技术的发展，需要以高空间分辨率量化机械功能。由于这些疗法是局部干预，因此需要一种具有高空间分辨率的全视野技术来区分正常，患病和治疗的心肌。我们开发了一种相位相关算法，可以在高空间分辨率下测量心肌位移，并确定完整心脏中的区域机械功能。暴露猪心脏，并将高对比度的微粒置于心肌上。插入左心室的压力传感器使用电荷耦合设备相机将压力（LVP）与图像采集同步。以0.58 +/- 0.04mm的分辨率测量心肌的变形。在感兴趣区域（ROI）内，平均定义了21个位置的区域笔划功（RSW），定义为LVP相对于区域面积的积分，分辨率为27.1 +/- 2.7 mm2。为了改变区域的机械功能，在ROI周围的三个不同位置对心脏进行了调速。与起搏器位置无关，RSW的投资回报率下降。此外，在所有起搏规程中都观察到了从起搏器向外放射的RSW的增加梯度。这些数据证明了以高空间分辨率确定区域全场机械功能的能力，以及电起搏引起的重大变化。

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