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首页> 外文期刊>Journal of Biomechanics >The penetration of a soft solid by a liquid jet, with application to the administration of a needle-free injection.
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The penetration of a soft solid by a liquid jet, with application to the administration of a needle-free injection.

机译：通过液体射流渗透软固体，并用于无针注射。

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摘要

Liquid jet injections have been performed on human skin in vivo and silicone rubber using Intraject needle-free injectors. The discharge characteristics of the liquid jet were measured using a custom-built test instrument. The experiments reveal that a high-speed liquid jet penetrates a soft solid by the formation and opening of a planar crack. The fluid stagnation pressure required for skin penetration decreases with increasing diameter of the liquid jet. These findings are consistent with the slow-speed penetration of a soft solid by a sharp-tipped punch. It is demonstrated that the Shergold-Fleck sharp-tipped punch penetration model [Shergold, O.A., Fleck, N.A., 2004. Mechanisms of deep penetration of soft solids. Proc. Roy. Soc. Lond. A 460, 3037-3058.] gives adequate predictions for the pressure required to penetrate a soft solid by a high-speed liquid jet.
机译：已经使用Intraject无针注射器在人体皮肤和硅橡胶上进行了液体喷射注射。使用定制的测试仪器测量液体射流的排放特性。实验表明，高速液体射流通过形成和打开平面裂纹而穿透了软固体。皮肤渗透所需的流体停滞压力随着液体射流直径的增加而降低。这些发现与锋利的冲头以较低速度穿透软固体相一致。证明了Shergold-Fleck尖头冲头穿透模型[Shergold，O.A.，Fleck，NA。，2004。软固体深层渗透的机理。进程罗伊Soc。 nd 460，3037-3058。]对通过高速液体射流穿透软固体所需的压力给出了充分的预测。

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