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首页> 外文期刊>Journal of Biomechanics >Solute convection in dynamically compressed cartilage.
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Solute convection in dynamically compressed cartilage.

机译：解决动态压缩软骨中的对流问题。

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摘要

Chondrocytes depend upon solute transport within the avascular extracellular matrix of articular cartilage for many of their biological activities. Alterations to solute transport parameters may therefore mediate the cell response to tissue compression. While interstitial solute transport may be supplemented by convection during dynamic tissue compression, matrix compression is also associated with decreased diffusivities. Such trade-offs between increased convection and decreased diffusivities of solutes in dynamically compressed cartilage remain largely unexplored. We measured diffusion and convection coefficients of a wide range of solutes in mature bovine cartilage explant disks subjected to radially unconfined axial ramp compression and release. Solutes included approximately 500 Da fluorophores bearing positive and negative charges, and 10 kDa dextrans bearing positive, neutral, and negative charges. Significantly positive values of convection coefficients were measured for several different solutes. Findings therefore support a role for solute convection in mediating the cartilage biological response to dynamic compression.
机译：软骨细胞的许多生物学活性都取决于溶质在关节软骨的无血管细胞外基质内的转运。溶质转运参数的改变因此可以介导细胞对组织压缩的响应。虽然在动态组织压缩过程中，对流可以补充对流溶质，但基质压缩也与扩散率降低相关。在动态对流的软骨中增加对流和降低溶质的扩散性之间的这种权衡在很大程度上尚待探索。我们测量了成熟的牛软骨外植体圆盘中多种溶质的扩散系数和对流系数，这些径向和轴向无限制的轴向压缩和释放。溶质包括约500 Da带有正负电荷的荧光团，以及10 kDa带有正，中性和负电荷的葡聚糖。测量了几种不同溶质的对流系数的显着正值。因此，研究结果支持溶质对流在介导软骨对动态压缩的生物学反应中的作用。

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