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首页> 外文期刊>Journal of Biomechanics >The role of muscles in joint degeneration and osteoarthritis
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The role of muscles in joint degeneration and osteoarthritis

机译：肌肉在关节变性和骨关节炎中的作用

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The purpose of this work was to establish a controlled and reversible muscle weakness model for studying the effects of weakness on joint degeneration leading to osteoarthritis (OA). The knee extensor muscles of rabbits were injected with single or repeat doses of Botulinum type-A toxin (BTX-A) to partially inhibit acetylcholine (ACh) release at the neuromuscular junction. BTX-A-injected muscles atrophied, they became weaker and push-off forces during hopping were reduced compared to control. BTX-A injections had the greatest effect at short-muscle length and low-stimulation frequencies. Superimposing BTX-A injections on anterior cruciate ligament transection did not cause greater muscle atrophy or weakness than BTX-A injections alone. Monthly repeat injections could be used to keep muscles weak for half a year without any obvious adverse effects to the animals. Gross morphology of the knees and histology of articular cartilage suggested that, in some animals, 4 weeks of muscle weakness resulted in initial signs of joint degeneration, indicating that weakness may be an independent risk factor for joint degeneration leading to OA. (c) 2007 Elsevier Ltd. All rights reserved.
机译：这项工作的目的是建立一个可控制和可逆的肌肉无力模型，以研究无力对导致骨关节炎（OA）的关节变性的影响。兔子的膝盖伸肌注射单次或重复剂量的A型肉毒杆菌毒素（BTX-A），以部分抑制神经肌肉接头处的乙酰胆碱（ACh）释放。与对照相比，注射BTX-A的肌肉萎缩，变弱，跳下时的下推力降低。 BTX-A注射在短肌长度和低刺激频率下效果最大。与单独的BTX-A注射相比，在前交叉韧带横断处叠加BTX-A注射不会引起更大的肌肉萎缩或肌无力。每月重复注射可用于使肌肉保持半年无力，而对动物没有任何明显的不利影响。膝盖的总体形态和关节软骨的组织学表明，在某些动物中，4周的肌肉无力导致关节变性的初步迹象，这表明肌无力可能是导致OA的关节变性的独立危险因素。 （c）2007 Elsevier Ltd.保留所有权利。

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