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首页> 外文期刊>Journal of Biomechanics >On the cytoskeleton and soft glassy rheology.
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On the cytoskeleton and soft glassy rheology.

机译：关于细胞骨架和柔软的玻璃状流变学。

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摘要

The cytoskeleton is a complex structure within the cellular corpus that is responsible for the main structural properties and motilities of cells. A wide range of models have been utilized to understand cytoskeletal rheology and mechanics (see e.g. [Mofrad, M., Kamm, R., 2006. Cytoskeletal Mechanics: Models and Measurements. Cambridge University Press, Cambridge]). From this large collection of proposed models, the soft glassy rheological model (originally developed for inert soft glassy materials) has gained a certain traction in the literature due to the close resemblance of its predictions to certain mechanical data measured on cell cultures [Fabry, B., Maksym, G., Butler, J., Glogauer, M., Navajas, D., Fredberg, J., 2001. Scaling the microrheology of living cells. Physical Review Letters 87, 14102]. We first review classical linear rheological theory in a concise fashion followed by an examination of the soft glassy rheological theory. With this background we discuss the observed behavior of the cytoskeleton and the inherent limitations of classical rheological models for the cytoskeleton. This then leads into a discussion of the advantages and disadvantages presented to us by the soft glassy rheological model. We close with some comments of caution and recommendations on future avenues of exploration.
机译：细胞骨架是细胞主体内的复杂结构，负责细胞的主要结构特性和移动性。已经使用了广泛的模型来理解细胞骨架的流变学和力学（例如参见[Mofrad，M.，Kamm，R.，2006。细胞骨架力学：模型和测量。剑桥大学出版社，剑桥]）。从大量提议的模型中，软玻璃流变模型（最初是为惰性软玻璃材料开发的）由于其预测与在细胞培养物中测得的某些力学数据非常相似，因而在文献中获得了一定的关注。 ，Maksym，G.，Butler，J.，Glogauer，M.，Navajas，D.，Fredberg，J.，2001。缩放活细胞的微流变学。物理评论快报87，14102]。我们首先以简洁的方式回顾经典线性流变理论，然后研究软玻璃流变理论。在此背景下，我们讨论了观察到的细胞骨架行为和经典的细胞骨架流变模型的固有局限性。然后，这引起了对由软玻璃流变模型给我们带来的优缺点的讨论。我们以谨慎的评论和对未来勘探途径的建议结尾。

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