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首页> 外文期刊>Journal of Biomechanics >Finite element modeling of 3D human mesenchymal stem cell-seeded collagen matrices exposed to tensile strain.
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Finite element modeling of 3D human mesenchymal stem cell-seeded collagen matrices exposed to tensile strain.

机译：暴露于拉伸应变的3D人类间充质干细胞接种胶原蛋白基质的有限元建模。

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摘要

The use of human mesenchymal stem cells (hMSCs) in tissue engineering is attractive due to their ability to extensively self-replicate and differentiate into a multitude of cell lineages. It has been experimentally established that hMSCs are influenced by chemical and mechanical signals. However, the combined chemical and mechanical in vitro culture conditions that lead to functional tissue require greater understanding. In this study, finite element models were created to evaluate the local loading conditions on bone marrow-derived hMSCs seeded in three-dimensional collagen matrices exposed to cyclic tensile strain. Mechanical property and geometry data used in the models were obtained experimentally from a previous study in our laboratory and from mechanical testing. Eight finite element models were created to simulate three-dimensional hMSC-seeded collagen matrices exposed to different levels of cyclic tensile strain (10% and 12%), culture media (complete growth and osteogenic differentiating), and durations of culture (7 and 14 days). Through finite element analysis, it was determined that globally applied uniaxial tensile strains of 10% and 12% resulted in local strains up to 18.3% and 21.8%, respectively. Model results were also compared to experimental studies in an attempt to explain observed differences between hMSC response to 10% and 12% cyclic tensile strain.
机译：人间充质干细胞（hMSCs）在组织工程中的使用具有吸引力，因为它们能够广泛地自我复制并分化为多种细胞谱系。通过实验已经确定hMSC受到化学和机械信号的影响。然而，导致功能组织的化学和机械体外培养条件的结合需要更多的了解。在这项研究中，创建了有限元模型，以评估接种于承受周期性拉伸应变的三维胶原蛋白基质中的骨髓来源hMSC的局部加载条件。模型中使用的力学性能和几何数据是从我们实验室的先前研究和力学测试中获得的。创建了八个有限元模型，以模拟暴露于不同水平的循环拉伸应变（10％和12％），培养基（完全生长和成骨分化）和培养时间（7和14）的hMSC播种的三维胶原基质天）。通过有限元分析，确定全球应用的10％和12％的单轴拉伸应变分别导致局部应变分别高达18.3％和21.8％。还将模型结果与实验研究进行了比较，以试图解释hMSC对10％和12％循环拉伸应变的响应之间的差异。

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