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首页> 外文期刊>Journal of Biomechanics >PREDICTIVE VALUE OF PROXIMAL FEMORAL BONE DENSITOMETRY IN DETERMINING LOCAL ORTHOGONAL MATERIAL PROPERTIES
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PREDICTIVE VALUE OF PROXIMAL FEMORAL BONE DENSITOMETRY IN DETERMINING LOCAL ORTHOGONAL MATERIAL PROPERTIES

机译：股骨近端骨密度测定法在确定局部正交材料性能中的预测价值

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Models which are based on non-invasive bone measurements may in the future be able to successfully identify individual subjects at an increased risk for hip fracture; thus, we designed a study to determine the usefulness of dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) in predicting the local material properties of human proximal femoral cancellous bone. There has been some disagreement in the scientific literature regarding appropriate predictive models for local material properties of cancellous bone. We sought to confirm that density-mechanical property relationships were consistent from subject to subject, and that three-dimensional QCT measurements were stronger predictors of mechanical properties than two-dimensional DXA results. Linear and power fit relationships between these densitometric measures and material properties were also examined to determine which were more appropriate. Bone cubes from specific regions of highly oriented trabeculae were analyzed separately to determine if cube orientation had an effect on mechanical properties independent of bone density. Ten pairs of ex vivo femurs (five male, five female; age 30-93, mean age 62) were prepared such that specific anatomic planes were visible radiographically. Both QCT and DXA measurements were made on all 20 femurs. Cancellous bone cubes were obtained proceeding along two distinct directions from the proximal end of each femur pair. Unexpectedly, the density-modulus relationships among these ten donors were found to be significantly different at p < 0.01 (83% of the tests were different at p < 0.0001). Density-strength regressions were also significantly different at p < 0.01, but this effect was not as consistent nor as statistically significant. In general, the QCT method did not produce predictions of local cancellous bone material properties superior to the DXA method. The linear and power fit models appeared to produce consistent results, with neither being obviously more advantageous. These density measurements explained at best 30-40% of the variance in modulus and 50-60% of the variance in ultimate stress. The orientation of cancellous cubes in the principal compressive trabeculae region was a significant contributor to mechanical properties (p = 0.0001) independent of bone density. This finding was not as dramatic in the femoral neck cancellous bone region. (C) 1996 Elsevier Science Ltd. [References: 22]
机译：基于无创骨测量的模型将来可能能够成功识别出髋部骨折风险增加的个体。因此，我们设计了一项研究，以确定双能X线骨密度仪（DXA）和定量计算机断层扫描（QCT）在预测人类股骨近端松质骨的局部材料特性方面的有用性。在科学文献中，对于松质骨的局部材料特性的适当预测模型存在一些分歧。我们试图确认对象之间的密度-机械性能关系是一致的，并且与二维DXA结果相比，三维QCT测量是更强的机械性能指标。还检查了这些光密度测量方法与材料特性之间的线性和幂拟合关系，以确定哪种更合适。分别对高度取向的小梁的特定区域的立方体进行了分析，以确定立方体的取向是否对机械性能有影响，而与骨密度无关。准备十对离体股骨（五男五女;年龄30-93，平均年龄62），以使特定的解剖平面在X线照相下可见。对所有20个股骨均进行QCT和DXA测量。从每个股骨对的近端沿两个不同的方向进行，获得松质骨块。出乎意料的是，发现这十个供体之间的密度-模量关系在p <0.01时显着不同（83％的测试在p <0.0001时不同）。密度-强度回归在p <0.01时也有显着差异，但是这种影响既没有一致性，也没有统计学意义。通常，QCT方法无法产生优于DXA方法的局部松质骨材料特性的预测。线性拟合和幂拟合模型似乎产生一致的结果，但两者都没有明显的优势。这些密度测量最多解释了模量变化的30-40％和极限应力变化的50-60％。松质立方体在主要压缩小梁区域中的取向是与骨密度无关的机械性能的重要贡献（p = 0.0001）。这一发现在股骨颈松质骨区域没有那么明显。 （C）1996 Elsevier Science Ltd. [参考：22]

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