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首页> 外文期刊>Journal of Biomechanics >A model of non-uniform lung parenchyma distortion.
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A model of non-uniform lung parenchyma distortion.

机译：不均匀的肺实质变形模型。

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A finite element model of mammalian lung parenchyma is used to study the effect of large non-uniform distortions on lung elastic behaviour. The non-uniform distortion is a uni-axial stretch from an initial state of uniform pressure expansion. For small distortions, the parenchymal properties are linearly isotropic and described by two elastic moduli. However, for large distortions, the parenchyma has anisotropic non-linear elastic properties described by five independent elastic moduli dependent on the degree of distortion; they are computed for a range of distortions and initial pressures. Ez, the Young's modulus in the direction of stretch, increases significantly with distortion (epsilon(z)) while Ex, the Young's modulus in the plane perpendicular to the stretch, is approximately constant. The greater the initial pressure, the bigger the difference between the two moduli at larger distortion strains. The shear modulus G(xz) is approximately independent of degree of distortion except at the highest initial pressure. The Poisson's ratio, nu(xz) is approximately constant with distortion strain for lower initial pressures, but increases significantly with epsilon(z) at higher pressures. Model predictions of the relation between G(xz) and initial uniform inflation pressure show a good correlation with reported experimental data for small distortion strains in a range of species. The model also exhibits similar behaviour to the experimentally measured uni-axial large deformations of a tri-axially pre-loaded block of parenchyma (Hoppin et al., 1975, Journal of Applied Physiology 39, 742-751).
机译：哺乳动物肺实质的有限元模型用于研究大的不均匀变形对肺弹性行为的影响。非均匀变形是从均匀压力膨胀的初始状态开始的单轴拉伸。对于较小的变形，实质特性是线性各向同性的，并由两个弹性模量描述。但是，对于较大的变形，薄壁组织具有各向异性的非线性弹性特性，取决于变形程度，该特性由五个独立的弹性模量来描述。它们是针对一定范围的变形和初始压力计算的。 Ez是拉伸方向的杨氏模量，随着变形（ε（z））而显着增加，而Ex（垂直于拉伸方向的平面中的杨氏模量）则近似恒定。初始压力越大，畸变应变越大，两个模量之间的差异越大。剪切模量G（xz）大约与变形程度无关，除了在最高初始压力下。对于较低的初始压力，泊松比nu（xz）在形变应变下近似恒定，而在较高的压力下，ε（z）显着增加。 G（xz）与初始均匀膨胀压力之间的关系的模型预测表明，与报道的一系列物种中的小变形应变的实验数据具有良好的相关性。该模型还表现出与三轴预加载薄壁组织的实验测量到的单轴大变形相似的行为（Hoppin等，1975，Journal of Applied Physiology 39，742-751）。

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