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首页> 外文期刊>Journal of Biomechanics >Modelling the circle of Willis to assess the effects of anatomical variations and occlusions on cerebral flows.
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Modelling the circle of Willis to assess the effects of anatomical variations and occlusions on cerebral flows.

机译：对Willis圆建模，以评估解剖学变异和阻塞对脑血流的影响。

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Blood flow in the circle of Willis (CoW) is modelled using the 1-D equations of pressure and flow wave propagation in compliant vessels. The model starts at the left ventricle and includes the largest arteries that supply the CoW. Based on published physiological data, it is able to capture the main features of pulse wave propagation along the aorta, at the brachiocephalic bifurcation and throughout the cerebral arteries. The collateral ability of the complete CoW and its most frequent anatomical variations is studied in normal conditions and after occlusion of a carotid or vertebral artery (VA). Our results suggest that the system does not require collateral pathways through the communicating arteries to adequately perfuse the brain of normal subjects. The communicating arteries become important in cases of missing or occluded vessels, the anterior communicating artery (ACoA) being a more critical collateral pathway than the posterior communicating arteries (PCoAs) if an internal carotid artery (ICA) is occluded. Occlusions of the VAs proved to be far less critical than occlusions of the ICAs. The worst scenario in terms of reduction in the mean cerebral outflows is a CoW without the first segment of an anterior cerebral artery combined with an occlusion of the contralateral ICA. Furthermore, in patients without any severe occlusion of a carotid or VA, the direction of flow measured at the communicating arteries corresponds to the side of the CoW with an absent or occluded artery. Finally, we study the effect of partial occlusions of the communicating arteries on the cerebral flows, which again confirms that the ACoA is a more important collateral pathway than the PCoAs if an ICA is occluded.
机译：使用压力和流波在顺应性血管中传播的1-D方程对Willis（CoW）圈中的血流建模。该模型从左心室开始，并包括供应CoW的最大动脉。基于已发布的生理数据，它能够捕获脉搏波沿主动脉，头臂分支和整个脑动脉传播的主要特征。在正常情况下以及阻塞颈动脉或椎动脉（VA）后，研究完整CoW的侧支能力及其最常见的解剖变化。我们的结果表明，该系统不需要通过连通动脉的旁通路来充分灌注正常受试者的大脑。在缺少血管或阻塞血管的情况下，连通动脉变得很重要，如果阻塞了颈内动脉（ICA），则前交通动脉（ACoA）比后交通动脉（PCoA）更关键。事实证明，VA的闭锁远不如ICA闭塞。就减少平均脑流出量而言，最糟糕的情况是在CoW中没有前脑动脉的第一段并伴有对侧ICA的闭塞。此外，在没有严重阻塞颈动脉或VA的患者中，在连通动脉处测得的血流方向对应于CoW一侧的动脉缺失或阻塞。最后，我们研究了连通动脉的部分阻塞对脑血流的影响，这再次证实，如果阻塞了ICA，则ACoA比PCoA更重要的侧支通路。

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