...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Biomechanics >Effects of suppression of bone turnover on cortical and trabecular load sharing in the canine vertebral body.
【24h】

Effects of suppression of bone turnover on cortical and trabecular load sharing in the canine vertebral body.

机译：抑制骨转换对犬椎体皮质和小梁负荷分担的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The relative biomechanical effects of antiresorptive treatment on cortical thickness vs. trabecular bone microarchitecture in the spine are not well understood. To address this, T-10 vertebral bodies were analyzed from skeletally mature female beagle dogs that had been treated with oral saline (n=8 control) or a high dose of oral risedronate (0.5mg/kg/day, n=9 RIS-suppressed) for 1 year. Two linearly elastic finite element models (36-mum voxel size) were generated for each vertebral body-a whole-vertebra model and a trabecular-compartment model-and subjected to uniform compressive loading. Tissue-level material properties were kept constant to isolate the effects of changes in microstructure alone. Suppression of bone turnover resulted in increased stiffness of the whole vertebra (20.9%, p=0.02) and the trabecular compartment (26.0%, p=0.01), while the computed stiffness of the cortical shell (difference between whole-vertebra and trabecular-compartment stiffnesses, 11.7%, p=0.15) was statistically unaltered. Regression analyses indicated subtle but significant changes in the relative structural roles of the cortical shell and the trabecular compartment. Despite higher average cortical shell thickness in RIS-suppressed vertebrae (23.1%, p=0.002), the maximum load taken by the shell for a given value of shell mass fraction was lower (p=0.005) for the RIS-suppressed group. Taken together, our results suggest that-in this canine model-the overall changes in the compressive stiffness of the vertebral body due to suppression of bone turnover were attributable more to the changes in the trabecular compartment than in the cortical shell. Such biomechanical studies provide an unique insight into higher-scale effects such as the biomechanical responses of the whole vertebra.
机译：对于脊柱的皮质厚度与小梁骨微结构，抗吸收治疗的相对生物力学效果尚不清楚。为了解决这个问题，分析了骨骼成熟的雌性比格犬的T-10椎体，这些犬已经用口服盐水（n = 8对照）或高剂量口服Rosedronate（0.5mg / kg /天，n = 9 RIS-抑制）1年。为每个椎体生成了两个线性弹性有限元模型（体素大小为36微米）-全椎骨模型和小梁房模型-并承受了均匀的压缩载荷。组织水平的材料特性保持恒定，以单独隔离微观结构变化的影响。骨转换的抑制导致整个椎骨（20.​​9％，p = 0.02）和小梁腔（26.0％，p = 0.01）的刚度增加，而皮质外壳的计算刚度（整个椎骨和小梁之间的差异）室刚度为11.7％，p = 0.15）在统计学上未改变。回归分析表明，皮层外壳和小梁腔的相对结构作用发生了细微但重要的变化。尽管受RIS抑制的椎骨的平均皮层外壳厚度较高（23.1％，p = 0.002），但对于RIS抑制的组，在给定的壳质量分数的情况下，壳承受的最大载荷较低（p = 0.005）。综上所述，我们的结果表明，在这种犬科动物模型中，由于抑制骨转换而导致的椎体抗压刚度的整体变化更多地是由于小梁腔的变化而不是皮质壳体的变化。这样的生物力学研究提供了对更大范围的效应（例如整个椎骨的生物力学响应）的独特见解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号