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首页> 外文期刊>Journal of Biomechanics >Orientation of collagen at the osteocyte lacunae in human secondary osteons.
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Orientation of collagen at the osteocyte lacunae in human secondary osteons.

机译：人次骨中骨细胞腔的胶原蛋白取向。

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摘要

This work characterizes an aspect of human bone micro-structure, pertinent to fracture initiation and arrest. It addresses how the orientation of elementary components proximate to osteocyte lacunae influences secondary osteon micro-biomechanics. New data at the perilacunar region concerning orientation of collagen-apatite, and prior data on collagen orientation outside the perilacunar region, are incorporated in a novel simulation of osteons to investigate how orientation relates to strains and stresses during mechanical testing. The perilacunar region was observed by confocal microscopy within single lamellar specimens, isolated from osteons. The specimens were separated by extinct or bright appearance in transverse section under circularly polarizing light. This is because synchrotron diffraction and confocal microscopy had established that each type, away from the perilacunar region, corresponds to specific dominant collagen orientation (extinct lamellae's dominant collagen forming small angles with the original osteon axis, while the bright lamellae's forms larger angles). Morphometry of serial confocal images of each perilacunar region showed collagen orientation generally following the orientation of canaliculi, circumambiently-perpendicular to the lacuna. The lacunae tilted relative to the lamellar walls were more numerous in extinct than in bright lamella. Their apices were less likely in extinct than bright lamella to show collagen following the canalicular orientation. The simulation of osteocyte lacunae in osteons, under tension or compression loading, supports the hypothesis that collagen orientation affects strains and stresses at the equatorial perilacunar region in conjunction with the presence of the lacuna. We further conjecture that collagen orientation diverts propagation of micro-cracks initiating from apices.
机译：这项工作的特点是与骨折的发生和停止有关的人体骨骼微观结构的一个方面。它解决了接近骨细胞腔的基本成分的取向如何影响继发性骨微生物的生物力学。围绕骨盆周围区域的胶原蛋白-磷灰石取向的新数据，以及围绕骨盆周围区域之外的胶原蛋白取向的先前数据，被整合到骨质的新型模拟中，以研究在机械测试过程中取向与应变和应力之间的关系。通过共聚焦显微镜在从骨质分离的单个板状标本中观察到了椎间隙周围区域。在圆偏振光下，通过横截面的消光或明亮外观来分离样品。这是因为同步加速器衍射和共聚焦显微镜已经确定，每种类型都远离腔周围区域，与特定的主要胶原蛋白方向相对应（灭绝的薄片状的主要胶原蛋白与原始骨轴成小角度，而明亮的薄片状形成较大的角度）。每个腔周围区域的连续共聚焦图像的形态测定法显示，胶原蛋白的取向通常遵循小管的周围，垂直于凹腔。相对于层状壁倾斜的凹腔在灭绝中比在明亮的层中更多。与明亮的椎板相比，它们的根尖在根管方向上显示胶原的可能性较小。在张力或压缩负荷下，骨质中骨细胞腔的模拟支持以下假说：胶原蛋白的取向会影响存在于腔内的赤道周腔区域的应变和应力。我们进一步推测，胶原蛋白的方向转移了从顶点开始的微裂纹的传播。

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