...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Biomechanics >Alterations in damage processes in dense cancellous bone following gamma-radiation sterilization.
【24h】

Alterations in damage processes in dense cancellous bone following gamma-radiation sterilization.

机译：γ射线灭菌后致密的松质骨损伤过程的变化。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Structurally intact cancellous bone allograft is an attractive tissue form because its high porosity can provide space for delivery of osteogenic factors and also allows for more rapid and complete in-growth of host tissues. Gamma radiation sterilization is commonly used in cancellous bone allograft to prevent disease transmission. Commonly used doses of gamma radiation sterilization (25-35 kGy) have been shown to modify cortical bone post-yield properties and crack propagation but have not been associated with changes in cancellous bone material properties. The purpose of this study was to determine the effects of irradiation on the elastic and yield properties and microscopic tissue damage processes in dense cancellous bone. Cancellous bone specimens (13 control, 14 irradiated to 30 kGy) from bovine proximal tibiae were tested in compression to 1.3% apparent strain and examined for microscopic tissue damage. The yield strain in irradiated specimens (0.93+/-0.11%, mean+/-SD) did not differ from that in control specimens (0.90+/-0.11%, p=0.44). No differences in elastic modulus were observed between groups after accounting for differences in bone volume fraction. However, irradiated specimens showed greater residual strain (p=0.01), increased number of microfractures (p=0.02), and reduced amounts of cross-hatching type damage (p<0.01). Although gamma radiation sterilization at commonly used dosing (30 kGy) does not modify elastic or yield properties of dense cancellous bone, it does cause modifications in damage processes, resulting in increased permanent deformation following isolated overloading.
机译：结构完整的松质骨同种异体移植物是一种有吸引力的组织形式，因为其高孔隙率可以为成骨因子的输送提供空间，还可以使宿主组织更快，更完整地向内生长。 γ射线灭菌通常用于同种异体骨移植中，以防止疾病传播。已显示常用剂量的伽马射线辐射灭菌（25-35 kGy）可以改变皮质骨的屈服特性和裂纹扩展，但与松质骨材料特性的变化无关。这项研究的目的是确定辐射对致密松质骨中弹性和屈服特性以及微观组织损伤过程的影响。对来自牛胫骨近端的松质骨标本（13个对照，14个辐照至30 kGy）进行了压缩测试，压缩至表观应变为1.3％，并检查了微观组织损伤。辐照样品的屈服应变（0.93 +/- 0.11％，平均值+/- SD）与对照样品的屈服应变（0.90 +/- 0.11％，p = 0.44）没有差异。考虑到骨体积分数的差异后，两组之间没有观察到弹性模量的差异。但是，受辐照的标本显示出更大的残余应变（p = 0.01），增加的微裂缝数量（p = 0.02）和减少的交叉影线型破坏量（p <0.01）。尽管常用剂量（30 kGy）的伽马射线灭菌不会改变致密松质骨的弹性或屈服特性，但确实会导致损伤过程的改变，导致孤立超载后永久变形增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号