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首页> 外文期刊>Journal of Biomechanics >Does subcutaneous adipose tissue behave as an (anti-)thixotropic material?
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Does subcutaneous adipose tissue behave as an (anti-)thixotropic material?

机译：皮下脂肪组织是否表现为（抗）触变材料？

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摘要

Although subcutaneous adipose tissue undergoes large deformations on a daily basis, there is no adequate mechanical model to describe the transfer of mechanical load from the skin throughout the tissue to deeper layers. In order to develop such a non-linear model, a set of experimental data is required. Accordingly, this study examines the long term behavior of adipose tissue under small strain and its response to various large strain profiles. The results show that the shear modulus dramatically increases to about an order of magnitude after a loading period between 250 and 1250 s, but returns to its initial value within 3 h of recovery from loading. In addition, it was observed that the stress-strain responses for various large strain history sequences are reproducible up to a strain of 0.15. For increasing strains, the stress decreases for subsequent loading cycles and, above 0.3 strain, tissue structure changes such that the stress becomes independent of the applied strain. From the results, it can be concluded that adipose tissue likely behaves as an (anti-) thixotropic material and that a Mooney-Rivlin model might be appropriate to simulate behavior at physiologically relevant high strains. However, before the model is developed more fully, further experimental research is needed to ratify that the material is (anti-)thixotropic.
机译：尽管皮下脂肪组织每天都会发生大的变形，但尚无足够的力学模型来描述机械负荷从皮肤到整个组织向更深层的转移。为了开发这样的非线性模型，需要一组实验数据。因此，本研究考察了脂肪组织在小应变下的长期行为及其对各种大应变曲线的响应。结果表明，在250到1250 s的加载周期后，剪切模量急剧增加到大约一个数量级，但在从加载恢复的3小时内恢复到其初始值。另外，观察到，对于各种大的应变历史序列，应力-应变响应是可再现的，直至0.15。对于增加的应变，应力在随后的加载循环中减小，并且在0.3应变以上时，组织结构发生变化，使得应力变得与所施加的应变无关。从结果可以得出结论，脂肪组织可能表现为（抗）触变材料，而Mooney-Rivlin模型可能更适合于模拟与生理相关的高应变行为。但是，在更全面地开发模型之前，需要进一步的实验研究来证明这种材料是（抗）触变的。

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