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首页> 外文期刊>Journal of Biomechanics >Effects of tissue preservation temperature on high strain-rate material properties of brain.
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Effects of tissue preservation temperature on high strain-rate material properties of brain.

机译：组织保存温度对大脑高应变率材料特性的影响。

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摘要

Postmortem preservation conditions may be one of factors contributing to wide material property variations in brain tissues in literature. The objective of present study was to determine the effects of preservation temperatures on high strain-rate material properties of brain tissues using the split Hopkinson pressure bar (SHPB). Porcine brains were harvested immediately after sacrifice, sliced into 2 mm thickness, preserved in ice cold (group A, 10 samples) and 37 degrees C (group B, 9 samples) saline solution and warmed to 37 degrees C just prior to the test. A SHPB with tube aluminum transmission bar and semi-conductor strain gauges were used to enhance transmitted wave signals. Data were gathered using a digital acquisition system and processed to obtain stress-strain curves. All tests were conducted within 4 h postmortem. The mean strain-rate was 2487+/-72 s(-1). A repeated measures model with specimen-level random effects was used to analyze log transformed stress-strain responses through the entire loading range. The mean stress-strain curves with +/-95% confidence bands demonstrated typical power relationships with the power value of 2.4519 (standard error, 0.0436) for group A and 2.2657 (standard error, 0.0443) for group B, indicating that responses for the two groups are significantly different. Stresses and tangent moduli rose with increasing strain levels in both groups. These findings indicate that storage temperatures affected brain tissue material properties and preserving tissues at 37 degrees C produced a stiffer response at high strain-rates. Therefore, it is necessary to incorporate material properties obtained from appropriately preserved tissues to accurately predict the responses of brain using stress analyses models, such as finite element simulations.
机译：死后保存条件可能是导致脑组织中广泛的物质特性变化的因素之一。本研究的目的是使用裂开的霍普金森压力棒（SHPB）来确定保存温度对脑组织高应变率材料特性的影响。处死后立即收获猪脑，切成2毫米厚，保存在冰冷（A组，10个样品）和37℃（B组，9个样品）盐水溶液中，并在测试前加热到37℃。带铝制传输杆和半导体应变仪的SHPB用于增强传输波信号。使用数字采集系统收集数据并进行处理以获得应力-应变曲线。所有测试均在死后4小时内进行。平均应变率是2487 +/- 72 s（-1）。具有标本级随机效应的重复测量模型用于分析在整个载荷范围内的对数转换应力-应变响应。具有+/- 95％置信带的平均应力-应变曲线显示出典型的功率关系，A组的功率值为2.4519（标准误差，0.0436），B组的功率值为2.2657（标准误差，0.0443），表明对B组的响应两组明显不同。两组的应力和切线模量均随应变水平的增加而增加。这些发现表明，储存温度会影响大脑组织的材料特性，并且在37摄氏度下保存组织会在高应变速率下产生更强的响应。因此，有必要整合从适当保存的组织中获得的材料特性，以使用应力分析模型（例如有限元模拟）准确预测大脑的反应。

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