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首页> 外文期刊>Journal of Biomechanics >Modeling the impact of concomitant aortic stenosis and coarctation of the aorta on left ventricular workload.
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Modeling the impact of concomitant aortic stenosis and coarctation of the aorta on left ventricular workload.

机译：模拟伴随主动脉瓣狭窄和主动脉缩窄对左心室工作量的影响。

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Coarctation of the aorta (COA) is an obstruction of the aorta and is usually associated with bicuspid and tricuspid aortic valve stenosis (AS). When COA coexists with AS, the left ventricle (LV) is facing a double hemodynamic load: a valvular load plus a vascular load. The objective of this study was to develop a lumped parameter model, solely based on non-invasive data, allowing the description of the interaction between LV, COA, AS and the arterial system. First, a formulation describing the instantaneous net pressure gradient through the COA was introduced and the predictions were compared to in vitro results. The model was then used to determine LV work induced by coexisting AS and COA with different severities. The results show that LV stroke work varies from 0.98J (no-AS; no-COA) up to 2.15J (AS: 0.61cm(2)+COA: 90%). Our results also show that the proportion of the total flow rate that will cross the COA is significantly reduced with the increasing COA severity (from 85% to 40%, for a variation of COA severity from 0% to 90%, respectively). Finally, we introduced simple formulations capable of, non-invasively, estimating both LV peak systolic pressure and workload. As a conclusion, this study allowed the development of a lumped parameter model, based on non-invasive measurements, capable of accurately investigating the impact of coexisting AS and COA on LV workload. This model can be used to optimize the management of patients with COA and AS in terms of the sequence of lesion repair.
机译：主动脉缩窄（COA）是主动脉阻塞，通常与二尖瓣和三尖瓣主动脉瓣狭窄（AS）相关。当COA与AS共存时，左心室（LV）面临双重血液动力学负荷：瓣膜负荷加血管负荷。这项研究的目的是建立一个仅基于非侵入性数据的集总参数模型，从而能够描述LV，COA，AS与动脉系统之间的相互作用。首先，介绍了描述通过COA的瞬时净压力梯度的公式，并将预测结果与体外结果进行了比较。然后使用该模型确定由不同严重程度的AS和COA共存引起的左室功。结果表明，左室卒中功从0.98J（无AS;无COA）到2.15J（AS：0.61cm（2）+ COA：90％）不等。我们的结果还表明，随着COA严重性的提高，将通过COA的总流量比例显着降低（从85％降至40％，COA严重性从0％变为90％）。最后，我们介绍了能够无创地估算LV峰值收缩压和负荷的简单制剂。总而言之，这项研究允许开发基于无创测量的集总参数模型，该模型能够准确调查AS和COA共存对LV工作量的影响。根据病变修复的顺序，该模型可用于优化COA和AS患者的管理。

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