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首页> 外文期刊>Journal of Biomechanics >Chemotaxis of mesenchymal stem cells within 3D biomimetic scaffolds--a modeling approach.
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Chemotaxis of mesenchymal stem cells within 3D biomimetic scaffolds--a modeling approach.

机译：3D仿生支架内的间充质干细胞的趋化性-一种建模方法。

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摘要

Bone tissue engineering is a promising strategy to repair local defects by implanting biodegradable scaffolds which undergo remodeling and are replaced completely by autologous bone tissue. Here, we consider a Keller-Segel model to describe the chemotaxis of bone marrow-derived mesenchymal stem cells (BMSCs) into a mineralized collagen scaffold. Following recent experimental results in bone healing, demonstrating that a sub-population of BMSCs can be guided into 3D scaffolds by gradients of signaling molecules such as SDF-1alpha, we consider a population of BMSCs on the surface of the pore structure of the scaffold and the chemoattractant SDF-1alpha within the pores. The resulting model is a coupled bulk/surface model which we reformulate following a diffuse-interface approach in which the geometry is implicitly described using a phase-field function. We explain how to obtain such an implicit representation and present numerical results on muCT-data for real scaffolds, assuming a diffusion of SDF-1alpha being coupled to diffusion and chemotaxis of the cells towards SDF-1alpha. We observe a slowing-down of BMSC ingrowth after the scaffold becomes saturated with SDF-1alpha, suggesting that a slow release of SDF-1alpha avoiding an early saturation is required to enable a complete colonization of the scaffold. The validation of our results is possible via SDF-1alpha release from injectable carrier materials, and an adaptation of our model to similar coupled bulk/surface problems such as remodeling processes seems attractive.
机译：骨组织工程是通过植入可生物降解的支架来修复局部缺损的一种有前途的策略，该支架会经历重塑并被自体骨组织完全替代。在这里，我们考虑一个Keller-Segel模型来描述骨髓间充质干细胞（BMSCs）进入矿化胶原蛋白支架的趋化性。根据最近在骨愈合方面的实验结果，表明可以通过信号分子（例如SDF-1alpha）的梯度将BMSC的亚群导入3D支架，我们考虑了在支架孔结构表面上的BMSC群体。毛孔内的化学吸引剂SDF-1alpha。生成的模型是耦合体/表面模型，我们将按照扩散界面方法重新制定模型，其中使用相场函数隐式描述几何形状。我们解释了如何获得这样的隐式表示，并在真实支架的muCT数据上给出了数值结果，假设SDF-1alpha的扩散与细胞向SDF-1alpha的扩散和趋化耦合。我们观察到支架被SDF-1alpha饱和后BMSC向内生长的减慢，这表明SDF-1alpha的缓慢释放避免了早期的饱和，是使支架完全定植所必需的。我们可以通过从可注射载体材料中释放SDF-1alpha来验证我们的结果，并且使我们的模型适应类似的本体/表面耦合问题，例如重塑过程，似乎很有吸引力。

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