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首页> 外文期刊>Journal of Biomechanics >A model for cell motility on soft bio-adhesive substrates.
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A model for cell motility on soft bio-adhesive substrates.

机译：在软生物粘附基质上的细胞运动性模型。

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摘要

Mechanical stiffness of bio-adhesive substrates has been recognized as a major regulator of cell motility. We present a simple physical model to study the crawling locomotion of a contractile cell on a soft elastic substrate. The mechanism of rigidity sensing is accounted for using Schwarz's two-spring model Schwarz et al. (2006). The predicted dependency between the speed of motility and substrate stiffness is qualitatively consistent with experimental observations. The model demonstrates that the rigidity dependent motility of cells is rooted in the regulation of actomyosin contractile forces by substrate deformation at each anchorage point. On stiffer substrates, the traction forces required for cell translocation acquire larger magnitude but show weaker asymmetry which leads to slower cell motility. On very soft substrates, the model predicts a biphasic relationship between the substrate rigidity and the speed of locomotion, over a narrow stiffness range, which has been observed experimentally for some cell types.
机译：生物粘附基质的机械刚度已被认为是细胞运动的主要调节剂。我们提出了一个简单的物理模型，以研究软弹性基质上的收缩细胞的爬行运动。刚度感测的机制是使用Schwarz的两弹簧模型Schwarz等人解释的。 （2006）。运动速度和底物刚度之间的预测依赖性在质量上与实验观察一致。该模型表明，细胞的刚性依赖性运动源于肌动球蛋白收缩力在每个锚定点处通过底物变形的调节。在较硬的基材上，细胞移位所需的牵引力获得较大幅度，但显示出较弱的不对称性，从而导致较慢的细胞运动。在非常软的基材上，该模型预测了在较窄的硬度范围内基材刚度与运动速度之间的两相关系，这在某些细胞类型上已通过实验观察到。

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